Sticky Acrocats, what were your IGF-1 results?

Discussion in 'Acromegaly / IAA / Cushings Cats' started by Venita, Jan 10, 2010.

  1. Venita

    Venita Well-Known Member

    Joined:
    Dec 28, 2009
    Copied and Reposted from the old board. http://www.felinediabetes.com/phorum5/read.php?15,1055552

    Acrocats, what were your IGF-1 results?
    Jess & Earl
    Date: May 6, 2008 09:07PM

    I've searched the board and it seems like >100 is considered indicative of acromegaly (MSU's normal range is 12-92), but I'd like to know what our acrocats' numbers have been. 120? Or more like 350?

    Edited to add: I did an IGF-1 test on SettleDown (nee Wilson) and the result was 44 (normal).


    Edited 2 times. Last edit at 08/28/08 11:57PM by Jess & Earl.

    ****************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Carolynn and Fletcher
    Date: May 7, 2008 08:43AM

    Fletcher's was listed as >203 (done at MSU) so the exact measurement couldn't be determined on the scale at that time.

    The interpretation stated: "The insulin autoantibody concentration is normal, but the insulin like growth factor concentration in this cat is extremely high and in a range consistent with the diagnosis of acromegaly."

    Carolynn

    ************************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Vanassa and China
    Date: May 7, 2008 09:50AM

    This is what the interpretation stated for China:

    "The elevated concentration of insulin-like growth factor 1 (IGF1) on this report is determined from dilution of this sample. Does this cat show physical changes that are consistent with acromegaly? It is recognized that elevations of this hormone may occur as a metabolic response to diabetes mellitus in some cats, but I think this result higher than what would be expected in that latter scenario". "

    China was listed as >275 and it was done at MSU as well.

    *************************************************************
    Re: Acrocats, what were your IFG-1 results?
    Posted by: Patti and Merlin
    Date: May 7, 2008 12:41PM

    Merlin's IGF-1 was 183 (done @ MSU). I have to admit I never asked to see the actual report (but I think I'll get it now). By the time I had the bloodtest done - I more or less knew Merlin had acromegaly because of his crazy numbers, his large insulin requirements AND that his buddy Fletcher (whose numbers Merlin matched) already had a + acrotest!

    *******************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Stephanie and Pheobe
    Date: May 7, 2008 01:29PM

    Oh Gosh......we have a different form of measurement over here - I know it was over 1,000 maybe over 1,200 - it was all over the phone with my vet and to be honest it was all a bit of a blurr....

    I'll ask Beth though - I remember I sent her a text so she may remember - I'll ask what Pickle's was as well. (I also try and get a conversion)

    ********************************************************************************


    Re: Acrocats, what were your IFG-1 results?
    Posted by: Dale Ann
    Date: May 7, 2008 02:02PM

    >147. Done at MSU, year - 2004.

    Edited 1 times. Last edit at 05/09/08 09:16AM by Dale Ann.

    ********************************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Beth & Pickles (Tam GA)
    Date: May 7, 2008 03:13PM

    Stephanie and Pheobe Wrote:
    -------------------------------------------------------
    > Oh Gosh......we have a different form of measurement over here

    Not really surprising.


    USA it's ng/ml and the rest of the world (SI units) it's nmol/L

    ng/ml to nmol/L divide by 0.131
    nmol/L to ng/ml multiply by 0.131

    I know that Pheobe's IGF-1 was higher than Pickles and hers was 1948 nmol/L (255 ng/ml). Anything over 1000 nmol/L (131 ng/ml) is deemed indicative of aromegaly at Cambridge Labs who does the testing for the UK and some of Europe.

    ****************************************************************

    Spunky is in the lead w/ 311... *NM*
    Posted by: Jennifer and Spunky
    Date: May 7, 2008 07:07PM

    *************************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Lara, Paddy (GA) & Maisie
    Date: May 8, 2008 03:57PM

    I was only told by my vet that Pad's had tested positive for Acromegaly, but when I got in touch with where the test had been carried out (Cambridge) they just said he was over 2000 (262), but didn't give me any more detail than that.

    For some reason Steph, I'd got it into my head that Pheobe had a more accurate number given that was lower than 2000 - but I guess if it was higher than Pickles, that doesn't leave much of a gap!

    I wonder if his levels would have been lower if I'd had the test done considerably earlier than I did - do they gradually increase over time or do they start and generally remain at the same level (assuming the hormone release doesn't have a break)?

    Lara

    **********************************************************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Deanie and Boo
    Date: May 8, 2008 04:38PM

    How can 3 tests run at the same lab have values of >147, >203 and >275?

    If Merlin's value was 185, why would any value be reported as >147? Their assay range evidently goes at least as high as 185 based on Merlin's result.

    Something's not right there.

    ***********************************************************************************************

    Re: Acrocats, what were your IFG-1 results?
    Posted by: Phoebe and Norton
    Date: May 8, 2008 05:08PM

    Could the test procedure / accuracy have been refined and improved over time?

    When were these tests done? Month/Year would be enough

    The testing accuracy / range would be dependent on the type and calibration of the equipment used - if that was changed or upgraded over time.

    ****************************************************************************************

    Norton (GA) IGF-1 = 331 *NM*
    Posted by: Phoebe and Norton
    Date: May 27, 2008 12:26PM

    **************************************************************************

    Madison IGF-1 = 582
    Posted by: Phoebe and Norton
    Date: August 21, 2008 09:58AM

    Joan and Madison currently post in the Lantus ISG.

    Sandy and BlackKitty are having blood drawn for the acro test today (also Lantus ISG posters)

    **********************************************************************************************

    Henrietta's IGH1 = 331 *NM*
    Posted by: C & Henrietta
    Date: August 27, 2008 08:07PM

    ******************************************************************************************

    Girlcat was 299 *NM*
    Posted by: Girlcat & Hope
    Date: September 7, 2008 11:40AM

    *******************************************************************************************
    wendy/milo IGF-1 = 345 *NM*
    Posted by: jojo and bunny(GA) and Y
    Date: November 29, 2008 01:26PM

    ***********************************************************************************

    sandy/cecil IGF-1 = 641 *NM*
    Posted by: jojo and bunny(GA) and Y
    Date: November 29, 2008 01:27PM

    ************************************************************************************

    Re: Acrocats, what were your IGF-1 results?
    Posted by: Wendi and Milo
    Date: January 1, 2009 11:43AM

    Just curious . . .
    Has anyone looked at what BG numbers the cat was having around the time of the test and/or how much insulin it was getting at the time?

    Since there is such a wide spread between IGF-1 numbers, I'm just wondering if their BG's & insulin amounts may have something to do with it what IGF # they got at the time of the test.

    Also, Milo has experienced at pretty much every dose along the way "better numbers" - then we have to raise the dose again, to see "better numbers, and so on. But, they have been (before the R) basically the same numbers no matter the dose.

    So, is his IGF-1 # possibly lower at better numbers? And with each dose increase does the IGF increase - is that why a dose works for a few days, then has to be raised again - does the IGF output compensate according to the amount of insulin, eventually making another dose increase necessary?

    Edited 1 times. Last edit at 01/01/09 11:58AM by Wendi and Milo.

    *****************************************************************************************************************************

    Insulin amounts & IGF-1 levels
    Posted by: Carolynn and Fletcher
    Date: January 2, 2009 07:51PM

    Looking back at Fletcher's bg's and doses, he was getting about 20-25U per day at diagnosis, yet a month earlier he was needing 40+ units a day. I do believe that when Fletch isn't needing insulin, that his IGF-1 levels would probably be normal (or close to it). Since the IGF-1 levels can fluctuate on a daily basis, it would make sense that when the insulin needs are higher, the IGF-1 levels would be higher, too, although (of course!) there are no studies on this.

    About the only way to know this would be to have our acrocats tested again to compare the levels of IGF-1 and insulin doses and see what the results are. That's definitely something I'd like to be able to do at some point.

    ***********************************************************************************************************************

    Libby's Sterling = 281 *NM*
    Posted by: Phoebe and Norton
    Date: January 10, 2009 03:06PM

    *****************************************************************************************************************

    Leo - 481 *NM*
    Posted by: Carolyn and Spot
    Date: January 16, 2009 05:02PM

    ********************************************************************************************

    Madison's follow up IGF-1 and cortisol levels
    Posted by: Joan and Madison
    Date: January 22, 2009 03:34PM

    cross-posted from High Dose ISG: http://www.felinediabetes.com/phorum5/read.php?25,1474401

    Maddie's first IGF-1 test was on 8/6/08. The result was 582. At that time, she was getting 8.5u Lantus b.i.d. plus generous doses of R. She was routinely in the 300s and 400s with an occasional 500 or high 200 number thrown in for variety.

    Her second IGF-1 test was done on 10/27/08 while she was at CSU for radiosurgery. The result was 569. Dr. Lunn also drew blood for adrenal function testing. At that time, Madison's Cortisol, Baseline was 293 and her Cortisol, 1 hr post ACTH was 432. During this time period, Madison was getting 20u Levemir (rarely any R), and was mainly in the 200s and 100s, with an occasional 300 or under-100 number.

    On 11/15/08, she had her first post-surgery follow up test. Her IGF-1 was 537. Madison’s Cortisol, Baseline was 190 and her Cortisol, 1 hr post ACTH was 395. During this time period, her insulin needs were changing drastically. On the date of the test, she got 7u Lev + 2u R. Her numbers were sort of ugly, 400s and 500s, but once I got her back where she belonged (for that time), at 12u, her numbers got better. Shortly thereafter, she earned a rapid series of dose decreases again.

    Her most recent post-surgery testing was on 12/15/08. I just got her test results back. Madison’s Cortisol, Baseline was 196 and her Cortisol, 1 hr post ACTH was 371. Her IGF-1 was up to 713! On 12/15/08, she was getting 6u Lev. Things were changing rapidly, so her numbers were up and down as I tried to find her new correct dose. Her numbers on 12/15/08, the date the blood was drawn for the IGF-1 test, her numbers were great, though.

    It makes no sense to me that her IGF-1 could be up to 713, but her insulin needs decreasing. Any thoughts/comments?

    =========

    Sarah (Dusty) from the catacromegaly.com board wrote to me:

    "I have no idea what is going on now with Maddie, but I found this article that says that IGF_1 has been tried as a treatment for diabetes: http://en.wikipedia.org/wiki/Insulin-like_growth_factor_1

    Check this one out also: http://ndarc.med.unsw.edu.au/ndarcweb.nsf/resources/NDARCFact_Drugs2/$file/IGF-1+NDARC+FACT+SHEET.pdf

    IGF-1 has been manufactured recombinantly on a large scale using both yeast and E. coli. Several companies have evaluated IGF-1 in clinical trials for a variety of indications, including growth failure, type 1 diabetes, type 2 diabetes, amyotrophic lateral sclerosis (ALS aka "Lou Gehrig's Disease"), severe burn injury and myotonic muscular dystrophy (MMD). Results of clinical trials evaluating the efficacy of IGF-1 in type 1 diabetes and type 2 diabetes showed great promise in reducing hemoglobin A1C levels, as well as daily insulin consumption. However, the sponsor, Genentech, discontinued the program due to an exacerbation of diabetic retinopathy in patients coupled with a shift in corporate focus towards oncology. Cephalon and Chiron conducted two pivotal clinical studies of IGF-1 for ALS, and although one study demonstrated efficacy, the second was equivocal, and the product has never been approved by the FDA."

    In the wiki article, it notes that: "..levels do not fluctuate greatly throughout the day for an individual person..." I wonder if that has been determined to be true for felines. I've been thinking about some questions that I want to ask Dr. Lunn (she's doing the radiosurgery trial study at CSU that Madison participated in) next time I talk to her. Does anyone have any suggestions?

    Edited 1 times. Last edit at 01/22/09 03:36PM by Joan and Madison.

    ************************************************************************
    nina/KB IGF-1 = 317 *NM*
    Posted by: jojo and bunny(GA) and Y
    Date: February 3, 2009 10:43AM

    ****************************************************************************
    christina/Stormy IGF-1=521
    Posted by: chriscleo
    Date: February 19, 2009 05:36PM

    test results came back 2/17/09.

    ********************************************************************************

    Notes from an Acroperson
    Posted by: Megan and Black Bear
    Date: February 24, 2009 04:05PM

    I have been reading all of your posts about your acrokitties with great interest. I have had symptoms of acromegaly for six years. My MRI's were "ambiguous" until a year and a half ago, when I had my first seizure. Shortly after that, my IGF1's started rising above normal. It was only then (after years of desperately trying to get doctors to believe that something was happening) that I could persuade an endocrinologist to even order the confirmatory "gold-standard" test for acromegaly in humans, the OGGT or oral glucose tolerance test. These came back positive; I got diagnosed with acro last summer and had surgery last September.

    I've been working on a post about what it feels like to have this disease, which I want to post on the High-Dose forum. I have so much admiration and sympathy for you and your kitties. As for this question, in humans the IGF1 represents an average over time, not a snapshot, and thus shouldn't reflect day to day changes. That said, I've had double tests drawn at the same time come back with readings 20 numbers apart.

    None of my experience has suggested that fluctuations in BG immediately affect IGF1 readings, but I'm not *really* a cat

    On the other hand, everything in my experience has taught me to trust my own perceptions and observations first, and the lab numbers second. I've earned my insights. You *know* your cats better than any lab test does.

    ****************************************************************************
    Re: Notes from an Acroperson
    Posted by: Vanassa and China
    Date: February 24, 2009 04:13PM

    Wow Megan! This is really interesting! I would love to hear more about how it feels to have Acro. Although my baby has gone on to a better place now, I am very curious as to how he may have felt during the process the entire process. Please feel free to PM me or post on the board, as I am sure that others are curious as well- especially in the hi-dose group because most of us battle with Acro on a daily basis.

    *****************************************************************************************************

    Re: Notes from an Acroperson
    Posted by: Beth & Pickles (Tam GA)
    Date: February 24, 2009 05:40PM

    We have often wanted to talk to human acromegalics, to try to get an understanding what it might be like for our feline friends. Thank you for posting.

    Megan and Black Bear Wrote:
    -------------------------------------------------------
    > None of my experience has suggested that
    > fluctuations in BG immediately affect IGF1
    > readings, but I'm not *really* a cat

    BG fluctuations are a result of changes in the IGF-1 levels. BGs don't affect IGF-1 levels.

    **************************************************************************************************************

    Re: Acrocats, what were your IGF-1 results?
    Posted by: mrmush
    Date: March 7, 2009 04:20PM

    Sam Wade, diagnosed MSU 11/08 IGF-1 = 433

    **************************************************************************************************

    bonnie/porscha IGF-1 = 357 *NM*
    Posted by: jojo and bunny(GA) and Y
    Date: March 13, 2009 06:47PM

    ************************************************************************************************
    Buckwheat IGF-1 = 196 ... IAA = 0
    Posted by: KT & Buckwheat
    Date: April 15, 2009 04:28PM

    He has a differential diagnosis.

    http://www.felinediabetes.com/phorum5/read.php?25,1606066

    KT & Buckwheat

    *********************************************************************************************

    Boo-ki = 407
    Posted by: Joan and Madison
    Date: April 25, 2009 01:23PM

    http://www.felinediabetes.com/phorum5/read.php?22,1636567,1636854#msg-1636854

    *************************************************************************************************

    Toby IGF-1 = 256; IAA = 2
    Posted by: Jill & Alex
    Date: April 27, 2009 11:28AM

    http://www.felinediabetes.com/phorum5/read.php?22,1639227,1639463#msg-1639463

    *****************************************************************************************************************

    Re: Acrocats, what were your IGF-1 results?
    Posted by: asil & mouf
    Date: May 14, 2009 12:26PM

    mouf just got results back... IGF-1 was 112..

    interpretation said: the IGF is only slightly elevated and not as high as we usually see in acromegaly..

    ****************************************************

    Juanita's Chika IGF-1 = 492
    Posted by: Jill & Alex
    Date: July 16, 2009 12:44PM

    http://www.felinediabetes.com/phorum5/read.php?22,1760049,1760162,sv=1#msg-1760162

    Edited 1 times. Last edit at 07/16/09 12:44PM by Jill & Alex.

    **********************************************************************************

    Re: Acrocats, what were your IGF-1 results?
    Posted by: Barbara and Misha
    Date: July 31, 2009 07:00PM

    For the record, Misha's was 381 in July 09. Done at MSU.

    Barbara

    Edited 1 times. Last edit at 07/31/09 07:01PM by Barbara and Misha.

    ******************************************************************************************************

    Kathy & Kitty IGF = 92?
    Posted by: Heather & Boo
    Date: August 1, 2009 09:04AM

    Can't find the exact number, but it was the high end of normal. Depending on how he does, Kitty might get tested again later on.

    **********************************************************************************************************
     
  2. Me and Bayley

    Me and Bayley Member

    Joined:
    Dec 30, 2009
    Bayley was just diagnosed yesterday - we are still absorbing this - her numbers were:

    IAA 7%
    Sematomedin 233
     
  3. Nancy and Cody

    Nancy and Cody Well-Known Member

    Joined:
    Jan 1, 2010
    Cody's IGF 1 = 280 (norm 12-92)
    done at MSU Feb 3-5, 2010
    IAA = 9 (+ = >20)
     
  4. OptOut

    OptOut Well-Known Member

    Joined:
    Dec 28, 2009
    2/26/10 Holly/Pablo IGF-1 397
    3/5/10 Gayle/Shadoe IGF-1 120; IAA 7%
    3/5/10 Jen&Milo IGF-1 247
     
  5. Karen and Obie

    Karen and Obie New Member

    Joined:
    Jan 6, 2010
    Hi everyone, I'm not very experienced in this board, but hope to learn more. After reading about high dose cats, I realized my Obie was probably acromegalic. Well, yep, he is! His IGF1 is 409!!! I have him up to 10 units levemir twice a day, but it seems he still needs more. He is incredibly hungry all the time. I switched him several months ago off of dry food. He is currently on Wellness cat food and gets a little piece of raw meat with his dinner. He also got a PLI done which shows him to have pancreatitis. What do I do now? I don't know how much to feed him! (He gets 1/2 of a 5.5 oz can three times a day. Is this too much, not enough. Acckkkk!

    Karen (and Obie)
     
  6. Shelly and Spaceman

    Shelly and Spaceman Member

    Joined:
    Feb 12, 2010
    It's official. Feeburt is anacro cat.
    I believe the IGF result was 396. Yikes.
     
  7. Blue

    Blue Well-Known Member

    Joined:
    Dec 28, 2009
    Oliver
    IGF-1 = 325
    IAA still pending result

    ETA: IAA = 60%
     
  8. Debbie and Bryce

    Debbie and Bryce Member

    Joined:
    Jan 14, 2010
    Bryce
    (5/29/2010) IGF-1 = 429 IAA = 8
    (10/1/2010) IGF-1 = 521
     
  9. WCF and Meowzi

    WCF and Meowzi Well-Known Member

    Joined:
    Dec 28, 2009
    1/7/08 Taco (GA) 388 (12-92)
    4/9/10 Betsy 389 (12-92)

    Both tests were done at MSU via Antech.

    Taco and Betsy were both strays, trapped and rescued by the veterinary clinic where Meowzi gets acupuncture treatments. There is some suspicion that the two cats are related, as they were both trapped in the same area. There were other strays rescued too, from the area. These were adopted by clients - the vets plan to keep an eye out for if any of these other kitties come in with FD, and will have them tested for acromegaly if they do.

    Taco's dose was up to 20u BID Lantus.

    Betsy is currently on 10u BID Lantus. She lives at the veterinary clinic, and is on mix of dry and canned food.
     
  10. Perry and Sooty

    Perry and Sooty Well-Known Member

    Joined:
    Sep 21, 2010
    Sooty's IGF-1 result just came in today: 285. (nmol/L)

    Test was done at MSU DCPAH, blood sample was drawn on 10/25/2010.

    DCPAH Endocrinology Interpretation:
    "The serum concentration of IGF1 is elevated and acromegaly remains as a differential diagnosis. Does this cat show physical changes that are consistent with acromegaly? It is recognized that elevations of this hormone may occur as a metabolic reponse to diabetes mellitus in some cats, but I think this result is higher than what would be expected in that latter scenario."

    The same report also provided the IAA result, which was 17% (normal, negative).
     
  11. kwhite

    kwhite New Member

    Joined:
    Jan 6, 2011
    Hi - I'm new to the FDMB. My cat has recently been diagnosed with Acro. I saw this question and got my paperwork out. This is what the dr. report shows: MSU - insulin-like growth factor-1= 477 --HIGH (n 12-92nmol/L) Interpretation by endocrinologist: cromeglly. DDX, can see elevations in GH to some extent with DM, but this level of elevation more likely cromeglly.

    I only looked through a few of the replies here, but this seems to be higher than what I've seen others post. We are waiting to get $$ estimates (and time involvement) for having radiation (?) treatment at either UC Davis or a place locally (Bay Area - Northern California). I'm concerned that we are going to spend a ton more $$ than we already have just diagnosing this, and we will lose him 6 mos to a year later. Not sure he is a happy camper anyway. He has long jack-rabbit back legs and has a little trouble walking properly, jumping up/down, etc. And his diabetes is totally out of control. He is on 20u a day of prozinc and last check in the office his BG was off the charts on the accu-read-thingy. I do not do any testing at home and he gets 2 shots a day.

    Anyway, that is where we are at. Any thoughts or comments will be appreciated.

    Thanks,
    Kristen and Calvin (about 12 yrs old. diagnosed with diabetes 9/2010, diagnosed with acro 11/2010)
     
  12. Girlcat

    Girlcat Member

    Joined:
    Dec 28, 2009
    Hi Kristen. There are a number of us with acro cats here on the board. i have put a call out for other acro moms to answer your post here. If u are considering having the surgery done there is a place Colorado State University ? w Dr Lunn that does treatment at a reduced rate that a number of acro moms here have taken advantage of over the past few years. I will have them answer you.As we speak one of our moms just had the procedure done yesterday.
     
  13. CocoButterBall

    CocoButterBall Member

    Joined:
    Mar 4, 2011
    Just got mine today.
    Coco is 249 for IGF
    IAA is 0%
     
  14. Charliemeow

    Charliemeow Well-Known Member

    Joined:
    Sep 20, 2010
    Charlie's results:
    igf-1: 262
    iaa: 22%
     
  15. hnkstr

    hnkstr Member

    Joined:
    Jun 12, 2011
    Tiggers Results diagnosed August 2011
    IAA = 60%
    Igf-1 = 377
     
  16. Marcy & Klinger (GA)

    Marcy & Klinger (GA) Well-Known Member

    Joined:
    May 9, 2010
    Klinger's results:
    IGF-1 116
    IAA 4
     
  17. Grayson & Lu

    Grayson & Lu Well-Known Member

    Joined:
    Jan 9, 2012
    Guess we've just joined this exclusive club...

    Grayson's results:
    IGF-1 236 (normal 12-92)
    IAA 50 (normal <20)

    dx 5/4/2012
     
  18. hmjohnston

    hmjohnston Well-Known Member

    Joined:
    Dec 30, 2011
    Sneakers results:
    IGF-1- 481
    IAA- 9

    dx 6-22-12

    **edited- just got the actual results from the vet and she was 481- not 419. Either I transposed or they did.
     
  19. BuzzFabbs

    BuzzFabbs New Member

    Joined:
    Apr 25, 2013
    Hi – newly diagnosed Acro cat. I'm Amy, the cat is Thor. His IGF score was 270 – he's a bit of an over-achiever. His BG levels are through the roof too – 600+ consistently for weeks. Trying to convince him that lower numbers are better...
     
  20. jessdonof

    jessdonof New Member

    Joined:
    Nov 25, 2013
    Lily was diagnosed in November 2013 and her IGF-1 was 533.
     
  21. Larry and Kitties

    Larry and Kitties Well-Known Member

    Joined:
    Dec 28, 2009
    Just received results for MurrFee from MSU:
    Insulin-like grown factor 1: >521
    Insulin antibody: 0
     
  22. Magda

    Magda Member

    Joined:
    Feb 12, 2016
    newly diagnosed -Menda IGF-1 >521
    IAA normal.
     
  23. JeffJ

    JeffJ Well-Known Member

    Joined:
    Jul 7, 2016
    IGF-1 = 305, where normal= (12-92nmol/L)
    Acromegaly confirmed.
    Physical exam found:
    - slightly clubbed feet
    - heavily thickened claws
    - protrusion of the mandible (prognathia inferior)

    Insulin dosage = 14.0 to 14.5 on 9/3/2016, to keep BG in the 250-400 range.
    Leo's FDMB thread during diagnosis period.
    .
     
  24. Adrian and Chino

    Adrian and Chino Well-Known Member

    Joined:
    Dec 8, 2016
    IGF-1 = 317, IAA = 0.
     
  25. Bronx's dad

    Bronx's dad Well-Known Member

    Joined:
    Nov 30, 2016
    Bronx
    12/16/16 IGF1-434, IAA 8 (neg).
    3/9/17 IGF1-405
     
    Last edited: Sep 14, 2017
  26. Mom2Maverick

    Mom2Maverick Member

    Joined:
    Dec 15, 2016
    We are also joining this club. Tested at MSU IGF-1=361, IAA=51.
    I'm confused as the test is reported as nmol/l and the articles I have read refer to acro as over 1000 nmol/l
    If I divide 361 by 0.131 I get 2,755 which is well above 1000. Is it possible that MSU is measuring in ng/ml and has nmol/l on their report as a reference in error? I haven't seen any cats here over 1000 tested at MSU.

    I copied this from the beginning of this thread.
    USA it's ng/ml and the rest of the world (SI units) it's nmol/L

    ng/ml to nmol/L divide by 0.131
    nmol/L to ng/ml multiply by 0.131

    I know that Pheobe's IGF-1 was higher than Pickles and hers was 1948 nmol/L (255 ng/ml). Anything over 1000 nmol/L (131 ng/ml) is deemed indicative of aromegaly at Cambridge Labs who does the testing for the UK and some of Europe.
     
    JeffJ likes this.
  27. Adrian and Chino

    Adrian and Chino Well-Known Member

    Joined:
    Dec 8, 2016
    Divide nmol/L by 0.131 to get ng/mL (conversion factors found here). Chino's result was 317, which his original vet didn't believe was high enough for a diagnosis of acromegaly, even though I pointed out that the unit of measurement in everything that referenced 1000+ was different than the unit of measurement reported by MSU. 317 nmol/L = 2419 ng/mL. Needless to say, we have a new vet now. Welcome to the club. :bighug:
     
    JeffJ likes this.
  28. MJW

    MJW Well-Known Member

    Joined:
    Mar 29, 2017
    Yum 1/22/2018
    IGF-1 417 nmol/L (H)
    IAA 4% (negative)
     
  29. John Irene and TITAN

    John Irene and TITAN Member

    Joined:
    Aug 6, 2018
    Titan IGF-1 was over 2000 ng/mL according to the IDEXX labs report. It's odd, but IDEXX in UK are using ng/mL as their units, and MSU are using nmol/L,
    which should be the SI units. The molecular weight of IGF-1 is 7649 per Wikipedia, so 2000 ng/mL is 2000/7649(grams to moles) times 1000(milli litres to litres)
    =262 nmol/L. Like Adrian and Chino said. This is the opposite of what was posted at the beginning of the thread, but two opposites make it right, so to convert from USA to Europe you divide by 0.131.
     
    JeffJ likes this.
  30. Mary Ann & Baby

    Mary Ann & Baby Member

    Joined:
    Aug 6, 2018
    Baby 10/04/2108 IGF-1 347 nmol/L (H). IAA 83%
     

Share This Page