Sorry to start a new thread but I couldn't figure out how to edit the subject of my old thread. Here's the background for Bruno. Bruno is 15.5 lbs now. http://www.felinediabetes.com/FDMB/threads/what-could-we-be-doing-wrong.184948/#post-2053820 We are up to 6 units BID of Lantus now. The curve after 7 days of 6 units was worse than what it was before. I just finished talking to our vet on the phone. I had emailed her our spreadsheet and told her that I am considering lowering the dosage back to 3 units and try incrementing by 0.5 units weekly because we had jumped by 1.0 unit instead of 0.5 unit since 2.0 units. We also had a few scattering lower number days back at 4 units. I suspected we might have missed a good dose at 3.5 or 4.5 if Somogyi was involved. Our vet dismissed that and told me that Somogyi could have been possible if our nadir was lower and since our nadir was always in the high teens, Somogyi was less likely. To be frank, I don't even know when his nadir is at because the few curves that I did showed no definite time when the nadir is at. We have also tried different food including Purina DM from the vet and has now gone back to Dr. Lisa's diet. She has asked us to go up to 7 units for a week. I have already done 3.0 units for 1.5 days and now don't know whether to defy her and continue to stay at 3.0 units or go up to 7.0 units. I am also leery of jumping back up to 6 or 7 units after 1.5 days at 3.0 units. I have agreed to buy a new bottle/pen of Lantus since ours was 10 weeks old now. It's still clear but I am willing to try to rule out that the Lantus has gone bad. She did mention that it's possible Bruno is insulin resistant and Cushing decease is a possibility. I asked her whether there are blood tests that can screen for insulin resistance and she said no. Wendy had mentioned a couple of tests(IGF-1 and IAA) that can be done at University of Michigan, I guess our vet does not know about these. She said she will consult with an internist and get back to me on Cushing decease. She mentioned that if we are up to 2 units/kg without seeing any effect (In Bruno's case, his weight is about 7 kg so 14 units of Lantus), Cushing is possible. At least that's my understanding from our conversation. She told me to get a new bottle and try 7 units BID. I am now at a crossroad not knowing what to do. I could continue at 3.0 units and possibly get a new vet or ease him back up to 6.0 units for a few days and continue onto 7.0 units. Any suggestions will be greatly appreciated.