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Info Feline Diabetes and Glucose Toxicity links

Discussion in 'Lantus / Basaglar (glargine) and Levemir (detemir)' started by julie & punkin (ga), Feb 5, 2012.

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  1. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
    A couple of weeks ago i decided to research online to see what exactly is happening inside of the body of a diabetic cat. i was particularly curious about the consequences of high blood sugar.

    Some of this is on humans, but it seems that type 2 diabetes is similar in humans and cats. i'm not a scientist and some of this is really complex but, for most of it, you can get the idea they are trying to convey. I won't try to interpret the articles and people will need to do their own research and draw their own conclusions. I'm just sharing what i found for those who are also interested in the question of "how does this all work."

    Each of the quotes below is just a glimpse at the information the article contains. The links will give you the entire article.

    Diabetes in Pets, Glucose Toxicity http://petdiabetes.wikia.com/wiki/Glucose_toxicity
    Amyloidosis http://petdiabetes.wikia.com/wiki/Amyloidosis
    Pathogenesis of Feline Diabetes Mellitus http://www.ncbi.nlm.nih.gov/pubmed/12431815?dopt=abstractplus
    Case Study: Glucose Toxicity, Type 1 or Type 2? http://clinical.diabetesjournals.org/content/23/1/44.full
    Management of New Onset Type 2 Diabetes http://www.medscape.com/viewarticle/428857 (You have to register with Medscape -free- to see article on their site, but i've copied it here.)

    Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes*http://www.jbc.org/content/279/41/42351.full
    Journal of Biomedical Chemistry

    More related articles from the University of Queensland:
    General Information - Diabetic Cats
    What Diet Should I Choose and How Should I Manage Problem Cats? (for vets) 2006, modified 2008

    Which Insulin Do I Choose and How Do I Adjust the Dose? 2006, modified 2008

    Management of Feline Diabetes: Home Monitoring

    Feline Diabetes Mellitus, by David Church World Congress 2006 http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2006&PID=15706&Category=2688&O=Generic

    7/4/2014 edited to fix broken links
  2. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
    Re: Feline Diabetes & Glucose Toxicity links

    bump for newbies . . . if you want to bookmark a topic so that you can come back to it later, at the bottom of the screen you'll see "bookmark topic." Click there and the link will be saved for you. to find it again, go to your user control panel, manage bookmarks, and it will be there.

    good idea to bookmark any topics that seem full of good info - on dentals, infections, pancreatitis, bouncing, etc. so you can refer to them when you need them in the future.
    LizzieInTexas likes this.
  3. tiffmaxee

    tiffmaxee Well-Known Member

    Nov 15, 2013
    • If using an insulin pen, the manufacturer recommends that the pen and cartridge be kept at room
    temperature and not refrigerated. This is to reduce the changes in volume of insulin dispensed
    associated with changes in temperature.

    This sentence caught my attention. Is it true? I'm about done with my first pen and it has been in the fridge and worked well but I still wonder about this.
  4. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
    that is true only for those who are using the pen needles that attach to the pen. The change in temperature apparently affects the volume dispensed when using the dialing mechanism at the end of the pen.

    Those using a syringe to withdraw the dose are not impacted by that dispensing mechanism. The insulin will keep longest in the refrigerator.
  5. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
  6. Jill & Alex (GA)

    Jill & Alex (GA) Senior Member Moderator

    Dec 28, 2009
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