Feline Diabetes & Glucose Toxicity links

Discussion in 'Acromegaly / IAA / Cushings Cats' started by julie & punkin (ga), Feb 5, 2012.

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  1. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
    A couple of weeks ago i decided to research online to see what exactly is happening inside of the body of a diabetic cat. i was particularly curious about the consequences of high blood sugar.

    Some of this is on humans, but it seems that type 2 diabetes is similar in humans and cats. i'm not a scientist and some of this is really complex but, for most of it, you can get the idea they are trying to convey. I won't try to interpret the articles and people will need to do their own research and draw their own conclusions. I'm just sharing what i found for those who are also interested in the question of "how does this all work."

    Each of the quotes below is just a glimpse at the information the article contains. The links will give you the entire article.

    Diabetes in Pets, Glucose Toxicity http://petdiabetes.wikia.com/wiki/Glucose_toxicity
    Amyloidosis http://petdiabetes.wikia.com/wiki/Amyloidosis
    Understanding Feline Diabetes Mellitus, Pathogenesis and Management http://www.uq.edu.au/ccah/index.html?page=43391&pid=0
    Centre for Companion Animal Health University of Queensland, Australia
    Professor Jacquie Rand, BVSc, DVSc, DACVIM (Who developed the Tight Regulation Protocol)
    Rhett Marshall, BVSc, MACVSc

    This one won't copy because it's a compressed pdf - perhaps one of you is smarter than me and can copy some of it here for others. This is probably the best and most specific of all of the articles in addressing our questions as caregivers of diabetic cats.

    Take a look at the lower right side of page 7, however for a key point. "Glucose toxicity contributes to loss of Beta cell secretion. Initially this toxicity is functional and reversible, but later it leads to permanent loss of Beta cells. Glucose toxicity is defined as impaired insulin secretion from chronic hyperglycemia. At a blood glucose concentration of 540mg insulin secretion is minimal by 3-7 days in previously normal cats."

    Pathogenesis of Feline Diabetes Mellitus http://www.ncbi.nlm.nih.gov/pubmed/12431815?dopt=abstractplus
    Case Study: Glucose Toxicity, Type 1 or Type 2? http://clinical.diabetesjournals.org/content/23/1/44.full
    Management of New Onset Type 2 Diabetes http://www.medscape.com/viewarticle/428857

    Chronic Oxidative Stress as a Central Mechanism for Glucose Toxicity in Pancreatic Islet Beta Cells in Diabetes*http://www.jbc.org/content/279/41/42351.full
    Journal of Biomedical Chemistry

    More related articles from the University of Queensland
    What Diet Should I Choose and How Should I Manage Problem Cats? (for vets) 2006, modified 2008

    Diabetes Mellitus in Cats (this article seems to be a subset of the link at the top of this post)

    Which Insulin Do I Choose and How Do I Adjust the Dose? 2006, modified 2008

    edited to add
    Feline Diabetes Mellitus, by David Church World Congress 2006 http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2006&PID=15706&Category=2688&O=Generic
  2. julie & punkin (ga)

    julie & punkin (ga) Well-Known Member

    Feb 17, 2011
  3. Squalliesmom

    Squalliesmom Well-Known Member

    Jun 26, 2015
    StephG likes this.
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