Hi Hollis, I've just had a look at Jai Jai's spreadsheet. I know the numbers are high, but you appear to be getting a much smoother curve on the 0.5IU dose of Lantus. If we can stabilise that curve over the next 5 cycles on 0.5 IU, then it will give a much better guide to where Jai Jai's dose needs to go next. The general idea is to keep a smooth curve then in stages tweak the dose a little every 6 cycles to lower that smooth curve into regulated numbers. (But there may well be bounces along the way.) Maybe think of it like going downstairs. At each step, Jai Jai's body needs to get used to the slightly lower numbers (otherwise the liver panics and starts dumping glucose into the blood and it sets off swings again.) .