Hi everyone. My kitty's name is Santino and he is a sweet 19-year old tabby who has never been sick a day in his life until just now. He got diagnosed with diabetes a few weeks ago (was losing weight, peeing everywhere and getting wobbly on his legs). We started Prozinc insulin (2 units twice a day) about 10 days ago. He was initially at 660 at the vet's office, and at the recheck today he was at 700! The vet told me that he might have an infection we haven't found on urine culture or anywhere else on the labs, so they gave him an antibiotic, and told me that I can go up a half a unit on the insulin. They also scared me saying that causes for insulin not working can include things like undiagnosed cancer, or simply the fact that elderly kitties can take longer for their insulin receptors to come back. That said, Santino's been acting a little better, though it might just be my imagination. He looks like he has more energy, is less off balance and wobbly while walking which my vet told me could have been a result of altered mental status due to high sugars, no longer has constipation, and doesn't seem to be drinking as much. He still has a lot of litterbox accidents, namely peeing all around the litter box and in it only about 20% of the time, but that might be a different issue entirely. Now, I've got a couple questions. 1. They told me to come in an hour before his insulin shot was due. That kind of doesn't make sense to me. Prozinc tends to wear off after 8-10 hours, no? So if he's tested right before he's given his shot with his last shot 12 hours ago, of course he will be high. Or am I missing something here? When you start a cat on insulin, is their sugar pre-dose eventually supposed to go down? This is something I really want to know. I'm catastrophizing now -- wondering if Santino has acromegaly... 2. I've compiled a list of low carb dry foods, does it seem reasonable: Wellness Core, Nature's Variety Instinct, Evo/Innova, Dr. Elsey's, Before Grain. I'll get several kinds and see which one Santino likes best. 3. I did leave my Prozinc out for about 8 hours once while I was at work. Rookie mistake, I know. The vial still looks ok, no cloudiness or stringiness. How long is it supposed to be good out of the fridge? 4. Could I be administering the shots wrong somehow? Any common pitfalls, i.e. furshots, insulin coming back out again after the poke? 5. If a cat is insulin resistant for whatever reason, is that the end? Is there no hope of them getting better? I have already learned a lot from this forum -- for instance, I had been feeding Santino FF with gravy, and then I read the label and guess what... the gravy is full of carbs. I've switched him back to FF classic pates today. Santino's also a kibble addict, but I will be transitioning him to a low-carb option. (I have Taste of the Wild Canyon River and an unknown type of Friskies that came from my mother in a bin, but neither of those seem like great options). I am going to try the home testing soon, but I live alone right now and work crazy hours, 8 am to 6 pm, and some days actually 24 hours straight through, though if I play my cards right I can have an hour long window in the middle to run home and give a shot.