It's a long story why Noah needs BUPE but in the beginning he hated the oral no matter what flavor. It was very stressful to both of us. For at least 18 months now he has been getting a transdermal mixture made by a compound pharmacy. Some vets have not heard of this. Noah's life went from sucking on a lemon to having his ears tickled. He gets 0.16mg/0.1ml TD twice a day. Continued success but a bit expensive, I never look at the bill!