Night before last Kitty had an episode where bd took huge drop in a couple of hours. Yesterday the Vet said to change dose of Vetsulin to .5 cu 1x daily. I have some questions about this. I thought Vetsulin had a 12 hr "life". The Vet said ECiD and that because she is outside exercising in the day her body was making enough insulin on it's own at that time. If you look at yesterday's SS you can see that w/o insulin her #'s actually did go down a little at the end of the day. This morning b/g was up but not as much as yesterday but still high 315. Gave her shot about 30 mins. ago and all is well. I'll get another test in a 1/2 hr. 1. Does the Vetsulin actually clear out of her body in 12 hrs? How does this effect dosing? If her AMPS is high do I increase/adjust dose on a daily basis or just go with the dose and expect that her body is going to make up for some of it through out the day? Since I'm only giving her 1 dose a day do you expect any overlap in a 24 hr. period with Vetsulin? 2. The Vet's original instructions were to give her 1 cu 1x a day and let it go. She was fine with my suggestion to go to the .5 cu 2x daily. My question is was the 1 cu 1x a day maybe a more appropriate dose in the first place. Before this change her numbers were getting more normal and so was her behavior. Her genetics are barn cat and I have noticed that outdoor exercise has a big impact on numbers which I'm sure was part of the explanation for the big fast drop night before last. This morning she's been doing fine but I am wondering if I can expect this to deteriorate through the day as the effects of only .5 cu daily kick in? I just want her #'s to come down to a more normal range. The day before the big drop was the best day we have had for months. She was her old self, active and interested rather than sleeping all day. Her condition has improved immensely since starting insulin and I would hate to lose ground. I have another set of questions on feeding and food prompted by the hypo instructions but will submit another question on that.