Pituitary Tumour with no Diabetes

Discussion in 'Acromegaly / IAA / Cushings Cats' started by Wendy & Eric, Jul 13, 2019 at 7:19 AM.

  1. Wendy & Eric

    Wendy & Eric New Member

    Joined:
    Saturday
    Hi, I'm not sure I have the right forum but there is very little information out there about Cushing cats. My 10 year old cat Eric has been polydipsia, polyuria & polyphagia since September 2018. After loads of tests the only abnormality was the urine creatine ratio which was initially 0.4 and now 0.27, also his pancreas markers were slightly high. So he's been on Simentra for protein in urine and Royal Canine Gastric Intestinal Moderate Calorie since February this year where he had an ultrasound on his adrenal glands at Dick White Referrals (UK). I will also add because of polyphagia he was piling on the weight 6.45kgs, after a strict diet he in now 4.6kgs. As none of the symptoms were disappearing all tests were repeated in April these included several low dex tests and 1GF-1 blood test which all returned normal. Finally a MRI was performed in May and this has diagnosed a large pituitary tumour. I have now been referred to RVC (UK) but initial discussions between them and Dick White Referrals say the tumour is slightly bigger than they would like for surgery and RVC want to have consult with Eric and I on 16th July. Does anyone else have experience of a cat with Cushings but not diabetes or agromegaly diagnosed? This is my second cat diagnosed with cushings Elsa was diagnosed in 2008, she was semi feral so never picked up the polydipsia and polyuria but I noted the polyphagia along with breathing difficulty. Within weeks she went to the skin tearing stage which was awful but we managed with baby grows, she was started on 30mg Vetoryl but 4 days later collapsed and died before I could get to the vets. Again she had no diabetes and we never got chance to do a scan. In the whole of my vet practice they have only seen two cats with cushings and I have both of them! Cats are rescued DSH not related.
     
  2. Sharon14

    Sharon14 Well-Known Member

    Joined:
    Aug 16, 2015
    I don’t know much about Cushings, but I’ll tag @Tuxedo Mom hopefully she can give you some insight
     
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  3. Jerry dutchboy

    Jerry dutchboy Member

    Joined:
    Mar 27, 2019
    Sorry to hear about little Eric. I'm sure that someone on here with experienced will be along to help. I'll keep an eye on your post during the day and bump it up if no response. It's weekend so folks may not be online too much. Hang in there.
     
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  4. JeffJ

    JeffJ Well-Known Member

    Joined:
    Jul 7, 2016
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  5. Wendy&Neko

    Wendy&Neko Well-Known Member

    Joined:
    Feb 28, 2012
    There have been cats with acromegaly but not diabetes, so I imagine it’s possible for Cushing’s too. We also had one Cushing’s kitty go into diabetic remission, here is the last part of her story http://www.felinediabetes.com/FDMB/threads/an-unfortunate-update.215766/

    Good luck with the visit to RVC. Keep us posted. I like to hear about the unusual, which often becomes the not so unusual here.
     
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  6. Wendy & Eric

    Wendy & Eric New Member

    Joined:
    Saturday
    Thank you everyone for the useful information I can definitely relate to the extreme hunger Eric tried to swipe a slice of melon out of my hand previously, he will eat anything even a screwed up piece of paper which he used to ping around playing with. It's like he is always living on the edge wondering where he can get food and water from next, it must be awful to feel like that 24/7.

    I will let you all know what the RVC advise.
     
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  7. Wendy & Eric

    Wendy & Eric New Member

    Joined:
    Saturday
    Well Eric come home with me today . The tumour is big and to complicate matters more they showed me a black area on MRI about the same size as mass above it. They don’t know what this is or if cells of tumour could be carried over into it, one suggestion was it could be blood from a previous bleed? The question I didn’t ask was if they managed to remove pituitary and tumour would they get a sample/biopsy of this black area. So if you treat the cushings symptoms only with adrenalectomy, you leave tumour to own devices. in their experience they were not always seeing good results with radiotherapy or Vetoryl options.

    After discussing all the options and weighing up Eric is a nervous cat for numerous visits were of the opinion that surgery on pituitary was the way to go but no guarantees and the unknown with black area above mass . For those who have had the operation what is the approximate cost of the hormone replacement tablets given after?

    Surgery can be done in the next 2 weeks, I need to discuss all with my home vet now as I value her opinion greatly having been through this with my previous cat Elsa.
     
  8. JeffJ

    JeffJ Well-Known Member

    Joined:
    Jul 7, 2016
    @sbluhrs is still active on the forum, and her cat Sophie had hypophysectomy last year. She would know the price of the meds.

    I'm curious what they quoted you for the adrenalectomy?

    I hope you can find a good solution for Eric, he looks very sweet in the picture.:bighug::bighug::bighug:
     
  9. Wendy & Eric

    Wendy & Eric New Member

    Joined:
    Saturday
    I didn't get a price for the adrenalectomy but can try and find out. Eric's option to do hypophysectomy was because the tumour is large and we don't know if the excess Cortisol the adrenal glands are producing now is slowing/shrinking tumour (like treating an inoperable brain tumour with steroids). If we remove adrenal glands we remove the cortisol in his system so felt best to tackle tumour.

    Eric is to be admitted to RVC on 29th July for CT scan and operation planned for Wednesday 31st July. So far RVC have done about 90 cats but all were acromegaly with tumours less than 7mm. Eric is the first with Cushings and tumour 11mm.
     
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  10. Wendy&Neko

    Wendy&Neko Well-Known Member

    Joined:
    Feb 28, 2012
    @John Irene and TITAN used to post about Titan, who had hypophysectomy at RVC, not sure he's still active now. Here is is post with the story: http://www.felinediabetes.com/FDMB/...t-diabetes-cured-by-pituitary-removal.200701/

    There is another thread that discusses meds post surgery, you will note that the exact meds differs somewhat between the UK and the US:
    http://www.felinediabetes.com/FDMB/...ussion-of-medication-and-other-issues.207078/
    The thyroid replacement tablets in Canada are cheap. I know some people you use them for hypothyroid cats.

    I wish you and Eric the best of results with the surgery. I thought RVC had done pituitary removal on one Cushings cat, but maybe it was other treatment. Anyway, I do remember somewhere reading about successful results from hypophysectomy and Cushings, but can't remember where. I think getting rid of the tumour is a good plan. We do see some kitties with neurological issues and blindness if the tumour is not treated.
     

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