I know I haven't kept my chart up to date, I DO have a notebook where I keep track of dosage, time, what I feed her, and her actions (not feeling well, etc) All is well, dosage has been reduced from 2.5 to 1.5. It was at 1.0 , but high numbers for a week made me bump it up to 1.5. Lately, her Preshot numbers run like 128, 137, and her nadir is in the 300s. I have never seen anything like it. My vial is getting old, but I don't think it's that.