I'll try to keep this short and to the point! Izzy has been consistently in the upper 300s to low 400s for a while now. He is on cerenia every three days and metronidazole twice a day. He was having issues with loose and rank smelling stool and consistent vomiting so I am afraid to take him off any of the medicine ( I believe I finally got the house to not smell like a pile of poo....) We have slowly been trying to up his dose and his numbers are not moving. A little over 3 weeks ago he started barfing and not eating and lost a few pounds. Since then we have been consistently keeping him on the above pills. We have not been pulling food for AMPS or PMPS since we do not want to put him off his food. We are at 3.5u for a day now (not long enough to tell anything) but when we were at 3u and asked our vet if we should increase she said, "I rarely have to go above 3" and did not recommend upping his dosage. He is a happy kitty and is running around with only mild neuropathy in his legs. He looks a lot better than he did 3 weeks ago and is at a normal weight. Externally he looks great! Internally I'm afraid of the damage that consistently being around 400 is doing. He is eating mostly wet food with some YAZ. I did test my meter against our civvie (much to his dismay) and my meter gave a normal number. I'm just looking for pointers on what our course of action going forward should be?