I'll post this on the old board too, but if you see this and have an answer, please reply, especially if you are a vet! Dr. Jen wants to put Ragnar (who is very infection-prone, possibly from his years of untreated IBD) on a maintenance dose of antibiotic, giving it twice a week instead of daily. I am skeptical because of my own 30 years' experience with antibiotics as a chronic UTI patient. I am sure this works the same in cats as in humans. My own experience tells me that if you give a low dose or stop an antiobiotic too soon, you will wipe out the least resistant bacteria and allow the most resistant ones to flourish. Therefore, you should hammer away with the antibiotic until the infection is gone, full dose, full steam ahead. Actually, my own chronic nephritis was wiped out by accident, when a doctor put me on a lifelong "maintenance dose" of Macrodantin and forgot to tell me or the pharmacist that it was one a day, not four. I kept getting bottles of Macrodantin that said "Take one capsule four times a day," took them for five years, and was cured. If I'd taken one a day, I'd still be taking them, and might be on dialysis by now or dead. Anyway - back to my original question: will low or intermittent doses prevent infection AND resistance, or will they "inoculate" the bacteria against the antibiotic and cause resistance to develop faster? Blessings!