I understand the importance of the protocol as a framework, but I don't really understand the 3 day (6 shot) rule for a cat with numbers as high as Yum's. Yum is clearly not going to go hypo if I increase her to 3u after 3 shots at 2.5u. Even if she did go hypo that might be good, since I would catch it and she would finally be out of the danger zone on the high end. Last spring she had to go to 4.5 before she started earning reductions. Her numbers are much higher now than they were then. Why can't I go higher a bit more quickly than 6 shots at each dose when I am clearly so far away from the correct dose? What are the arguments against being more aggressive? (1) The depot has to fill. I also don't understand why too high a dose can make a cat's numbers too high. Is that just because of the bounce? Is the nadir also too high? I don't think I've seen examples of that. I don't understand why too high a dose would cause high nadirs. I believe I read that for glucose toxicity, one has to race ahead in the dose. The damage occurs at high number and the dose requirement increases. The dose increase has to get ahead of the damage increase.