Hello Everyone, Long post coming up... I've been lurking here the last few weeks and decided to finally make an account and post. My cat Razor is 16 and was diagnosed with diabetes earlier in June at his comprehensive exam. His blood sugar had been iffy for a little while, likely due to his prednisolone usage (He has/had HORRRRRRIBLE allergies and the prednisolone is still necessary). Well, we had Razey on 1 unit of Vetsulin in the AM for about a week and a half. I changed his diet from his usual wet breakfast / dry free feed / wet dinner, to mostly all wet with some glycobalance kibble here and there. We also cut back his prednisolone from 1.4 ML every 2 days to 1 ML every 2 days. Everything was going pretty good. Then unfortunately around last Friday, Razey's appetite started to wane a bit and I noticed he hadn't pooped in a day or two. I took him to the ER last Saturday, they gave him the works. Glucose was fine (that was a day with no insulin, mind you). He had a blockage/constipation, gave him an enema and sent him home after he passed it. Took a day or two for his appetite to come back, but it did! Things were great. I was testing his glucose at home without any insulin & everything was wonderful, even a curve day (90-118 scores consistently). The vet spoke with a specialist and said it's very possible that Razor's diet change & medicine cutback kicked the diabetes in a matter of weeks. Unfortunately, I noticed that yet again he was becoming constipated. After 2 days of not pooping I decided to be proactive and take him back to the ER this past Friday. He yet again got flushed out, fluids, etc. But this time they sent him home with Lactulose. I read that lactulose should be OK for cats that have had diabetes problems. However, I have also read conflicting reports. Even my vet told me to let her know if something was awry. He pooped yesterday (Saturday) and his appetite returned almost instantly after his ER visit. His glucose was fine yesterday as well on my spot check (116). However, today, when I tested his glucose at 11:30 AM it was 156. This was after he had 2 small wet food meals (6 AM, 9 AM) and took his prednisolone (10 AM). I realized I had never actually tested him at home while on prednisolone, the days he was at the ER were prednisolone days so I didn't feel like prodding him more when he got home. I think administered his first dose of Lactulose of the day around Noon and out of curiosity tested his sugar again around 2:30... I saw the number was 222 and was shocked! Is it possible that he's having adverse blood glucose spike to both the lactulose & prednisolone? Or, god forbid, his diabetes came back already? I'm hoping it's the former. Tomorrow is a non-pred day & I'm thinking of not giving him any more lactulose to be safe and perhaps trying miralax if he doesn't go by tomorrow morning (which would be a shade over 30 hours). Any thoughts or help? I plan on testing his glucose once more this evening & tomorrow morning and hopefully conferring with my vet tomorrow when she's back in. Thank you!