So we've upped his dose to 3U BID and his blood ketones have dropped to 0.1mmol. Even at 3U he still doesn't seem to be curving any more than he did at 2U, and his nadir is around +7 or +8. The interesting thing is that he seems to drop quicker and lower at night for some reason confused_cat Are we at the point that we need to consider changing insulins? We have a vet appointment on Friday to check up on things. As of now, I plan on raising his dose tomorrow morning another 0.5U. So far he has gained a total of 1 pound back from his lowest weight a month and a half ago.