Howie went in today for a retest of IGF-1. His first one was done in Sept and came back normal at 83 (IAA came back positive at 63). But his incredible dosage of (now) 42u BID of Levemir that keeps going up along with using R isn’t cracking the antibodies. Many thanks to so many of you for answering so many of my earlier IAA questions! After reading a bunch about acromegaly, I will be shocked if this retest doesn’t come back positive based on some physical signs. But I am questioning (probably as I don’t want to believe he really has it!) whether what I am seeing are acro signs. I appreciate anyone’s thoughts/experiences. I asked the vet to do a full physical exam today of these signs/signals and he thinks everything is normal. Howie would be his first diagnosed acro kitty though. 1. He has been putting on weight (13.1#s today and was 12.1#s on Dec. 14). His lowest was 8.5#s in Sept before the IAA diagnosis and switching to Levemir. However, I’ve been feeding him 150-200% of his calories to get weight on him and know I need to back him off. I honestly can’t tell if he is pot bellied or if he just looks healthy? How does one know what the cats ideal weight is? He has always been a good eater unless he’s had intestinal issues occasionally. 2. he has recently started snoring occasionally when sleeping and sneezing more. But could the weight gain just cause the snoring on top of sleeping in a ball? Anyone else have snoring kittie? I asked the vet to look at his tongue to see if it’s enlarged, but he can’t tell. 3. He’s always had big front paws and bow legs. I got him in March and checked out fine. His FD diagnosis wasn’t until June. Attached are a few photos. They haven’t gotten any bigger so couldn’t this just be his body structure? 4. He had all his teeth removed in the first couple weeks of getting him so I honestly don’t know what his mouth/jaw structure was like prior to his teeth removal. Thanks!