Great that you're reading and asking questions! A "shed" or depot is how any drug builds up in the system. It creates what amounts to that is in storage vs. an amount that is directly available for use. Compared to other short or intermediate acting insulins, this is particular to Lantus and Levemir. It's what makes these insulins very different than Vetsulin. And, it makes Lantus and Levemir much more gentle with regard to use. It also allows for overlap between doses. It is also why you will need to stick with your starting dose of Lantus for between 5 - 7 days. It will take roughly that long for the shed to build.
I noticed your earlier post. The Lantus ISG operates a little differently than the Health board or the other ISGs. Because there are so many kitties here, we open one thread (we call them condos) per day, per cat. You'll see the way the subject lines are set up reflecting doses and we alter the subject line if there is a question or pressing issue. No worries at this point but it's more of a convention for all of us so we can keep track of everything.
I hope you will consider posting regularly/daily. There is a considerable difference between Lantus and Vetulin and you will pretty much need to forget everything that you know about dosing. Lantus dosing is not on a sliding amount and is not based on pre-shot BG levels. Dosing decisions are based on the nadir. Obviously, we get pre-shot BGs tests so we are not shooting blind but mid-cycle tests are extremely important.
When you have a chance, please visit the Tech Forum. There are instructions for creating both a spreadsheet and profile and how to link this information to your signature. This will provide everyone here with information about Hoyt's progress and his background, medical issues, etc. Please continue to ask questions. We will do our best to not overwhelm you!