I haven't posted on these forums for a while, and I'm not sure where to post this, but I thought I'd start by putting it here after seeing this post: http://www.felinediabetes.com/FDMB/threads/insulin-degludec-for-cats.187673/ I am starting Conan on Triseba tomorrow morning. If anyone is interested in following this experiment, I'd be happy to update as we go along - my vet is very supportive and we've talked a lot about it, but we're definitely going to be in unknown territory to a large extent. His case is not necessarily typical, as his diabetes was steroid-induced and he remains on steroids, making blood sugar regulation extremely challenging (and remission an impossibility). For the first six months after his January 2016 diagnosis he was on Lantus, but his numbers were all over the place and very unpredictable. Then we switched to Levemir. This was much more predictable (and effective) for him - but it lasted a much shorter time, generally 7 hours or less. He was on a 3x/day dosing schedule whenever I could manage it (which was not every day), but even then he often didn't make a full 8 hours on a dose. 3x/day dosing is very challenging, and so two weeks ago we decided to try the Lantus again. Right after that, I read about Triseba, and after discussing it with the vet at length, we decided it was worth a try. His current Lantus dose is 2.75, and he is not well regulated (yet?) on that dose. I'm going to begin the Tresiba at 1.5U 1x/day (in the Zurich studies, it lasted close to 24 hours for many cats; in people it can last up to 40-42 hours). The nature of this insulin seems to be that it can take a number of days to see the true effect of dose changes, so it will probably take a while to figure it out. If 1x/day dosing works, that could be great for pet owners - especially since the dosage timing for Tresiba, at least in humans, is supposed to be much more flexible. So I just thought it was worth a mention in case anyone is interested!