Okay. I'll go in to details below, but the gist of my question tonight is this - Is it normal for a cat not to respond to vetsulin for a month? And a half. Tiger was diagnosed on 07/09. For the past month, we've been increasing his dose because his numbers are always very high. Finally around 4u, we were at least seeing his nadir dropping. But just over this past week, while his pre shot numbers are still high (but lower than they have been ever! If you look at his sheet, allllllllll of those 600s are actually "high" readings - my human meter stops at 600, so I dont have anything more accurate than that. ) he has started dropping quite low with his insulin. I've been available to intervene this weekend when I've seen his numbers at their lowest, almost scary low (alright, actually scary low for me, though hes been acting fine - I have a thread in the main forum if you want to follow our weekend escapades) I have emailed my vet, and asked her professional opinion, but I might get a faster response here - is it normal to see this kind of reaction? Where it takes a month for the insulin to start having an effect? Should I continue to reduce his dose? I know giving too much too fast is dangerous, and I know that being a little too high for a day or two is way safer than being too low for any amount of time, but are there any concerns with messing around with his dose too much? I'm going to be switching to lantus when I'm done with this vial of vetsulin, so I dont know how much that might play in to things, if at all. My husband had also suggested the bottom of the vial of vetsulin being more potent than the beginning. I'm sorry I got rambly. I hope this makes enough sense to someone to give me an idea where to go from here.