it might not be news to some of you but Methimazole / Thiamazole is available in transdermal form. I've also had great success with transdermal BUPE both short term and long term. With our last sugar cat it never affected his numbers, no constipation, never had to keep him away from the stairs. This is always near the top of my profile: Transdermal BUPE Strength 0.16mg/0.1ml. Dose 0.05ml Every 8 to 12 hours as needed.