Saoirse spent a couple of days this week undergoing various diagnostic scans and tests. Based on the findings Saoirse has also been diagnosed with stage II CKD and hypothyroidism (which they think is related to the pancreatitis). There are some abnormalities in her liver, but the initial view is that these are likely to be fairly common, benign lesions. The specialist has put her on an analgesia trial (0.27 ml buprenorphine TID) to see if it might help reduce the pancreatic inflammation (latest Spec fPL 17 and significant swelling seen on scan). Saoirse has been treated with bupe before but only seemed to need occasional doses. A dose of 0.2ml last year didn't seem to agree with her much but it was hard to tell because her diabetes was not controlled at the time. She has tolerated very occasional doses of 0.1ml. I was concerned about the higher dose prescribed because Saoirse seems to be very sensitive to all medications (only needs tiny doses to benefit from the likes of ondansetron, cyproheptadine, famotidine). Earlier in the week Saoirse was only mildly symptomatic for pancreatitis (perky, excellent appetite, producing excellent stools, no nausea, very occasional brief periods of hiding after a meal now and again). This morning I woke up to find her hiding under a table and looking really, really ill. She didn't eat her overnight feeds. She seemed very lethargic after the second, larger dose of bupe last night. The only other variable was that I opened a new tin of food for her overnight feeds (from same batch as she had been on earlier in the week without any problems). I've seen her have iffy reactions to food many times, and this seemed very different. I've consulted our vets about this and we've agreed to withhold the bupe and monitor Saoirse's clinical signs over the weekend. Frankly, I'm not prepared to give her the bupe. I'm really, really worried about her reaction to the higher dose of the drug: she seemed way more poorly than she would be if had a bad reaction to a food, and goodness knows I've enough experience of that. Does anyone else know about or have experience of adverse reactions to buprenorphine? Does anyone know of a reputable site where I might find details of when the drug is contraindicated in cats? I've done a quick scout on Google and I've seen a couple of sites that say that buprenorphine is contraindicated in cats with renal issues and also hypothyroidism but I'd be very grateful if anyone could point me at a source that will be useful to my vets. I'm quite poorly myself after having to be away from home for a couple of days (agoraphobia, etc.) and I'm just not able to do a lot of research myself right now (if I was able to do i, I wouldn't be asking for a leg up). Can anyone recommend some respected veterinary sites that I might look up to find out more information fairly quickly? It would be such a help and very, very much appreciated.