Noah can slip into "high-dose/bouncer" mode if you look at him wrong. He's usually a tiny bit higher than I'd like but there's no in-between with him. I'm okay with all this, he eats despite his horrible teeth, his pain is managed, lots of stuff. Today I opened a new vial and I'll be hovering over him because that's how Caninsulin seems to work, it very slowly fades away. Does this happen to anyone else? Should I be starting a new vial every 14 days? No 2 fridges are the same and even if I kept a thermometer in there I can't control the temp that closely. I use the butter box. I just looked at 2 FAQs that were of no help! Why does Caninsulin seem to fade away? "The product should be used for 21 days, 28 days or 42 days after first opening, depending on the country. Considering I don't have a medical grade fridge what temperature blah blah.... "Vetsulin should not be frozen" Wow, thanks Doctor Of-No-Help-Whatsoever! Depending on the country??? I'm glad I'm not on Twitter because this little snippet was included. Is Vetsulin made here in the US? No, Vetsulin/Caninsulin are manufactured by Merck Animal Health in Germany. Sorry Donald, I'm doing the best I can. Is Puerto Rico an island? Where does everyone else keep their insulin? How come there's no White House dog?