I used to give Riley Glargine insulin, but switched vets and the new vet insisted on Vetsulin (plus I must use AlphaTrak2). Just started Vetsulin with the evening injection on February 2. When the vet gave me the insulin and syringes she didn't give any instructions other than telling me to give him one unit twice a day. I didn't "shake" the Vetsulin because you don't shake Glargine. I wasn't near any internet connection. If I had been, I would have checked here before starting. I gave him one unit twice a day morning and evening three times, watching his glucose climb higher and higher. I decided this morning to increase to 2 units because he's never had blood glucose this high for this long and increasing that much with Glargine in the past has not had a huge effect. I turned the vial over in my hand a couple of times because it seemed to be "cloudy". When I did this I mixed the ingredients so the insulin would have proper effect, but I didn't know it at the time. When I checked him mid-cycle, his glucose was 29. I gave him Karo syrup on top of some canned Friskies. After an hour he was OK. Now I'm not certain as to what to do this evening. I've read the information for newcomers regarding glucose and dosing levels, but this Vetsulin is evidently SOOO different from Glargine I'm having difficulty wrapping my head around it. Thanks for any advice.