Hi all, More detail on this thread: http://www.felinediabetes.com/FDMB/threads/how-to-handle-diarrhea.164284/#post-1777614 Story so far: Saoirse had a 3-day bout of diarrhoea after starting a new batch of her regular Sheba food (and civvie's poops on same batch were a bit suspect). I started slippery elm bark (SEB) and fed her from a different batch. Her appetite was not affected in the least during this time (eating heartily). Diarrhoea stopped after batch switch and 2nd dose of SEB. Saoirse had a normal, solid, healthy poop just over 24 hours later. At this stage Saoirse was in really great form, eating well and enjoying her food, happy (purring, affectionate, scent marking with her cheeks). I ran out of Saoirse's 'emergency' stock of food and I had to give her some more of the other batch (could not source a different batch locally). The diarrhoea returned within hours of her eating it. (I've reported this to the manufacturers.) As soon as Saoirse stopped eating this suspect Sheba batch the diarrhoea stopped again so both myself and the vet really think there was something amiss with it. I tried a different Sheba batch yesterday morning for AMPS meal. She ate this meal but would not eat any more (occasionally she'll turn her nose up at certain batches and she had not been keen on this particular batch before so nothing out of the ordinary at this stage). I have an emergency alternative food (Kattovit Sensitive Chicken) that Saoirse eats occasionally so she had some of that. After eating the 2nd meal of this food she started growling. She was completely inappetent by PMPS yesterday - wouldn't even lick some i/d gravy or SEB syrup from my fingers. I had to skip her insulin dose last night. (PMBG was 8.1.) Last night Saoirse got famotidine, ondansetron and 1/8 of a 4mg cyproheptadine tablet (and a quite reasonable amount of water via syringe). About 7 hours after eating the Kattovit paté she produced a poop which looked very much like undigested Kattovit but the stool, while very soft, was better formed than what she was producing on the dodgy Sheba (that was gelatinous, tan-coloured and malodorous). Saoirse vomited clear liquid in the small hours (presumably from the acid build-up due to her stomach being empty - that and constipation are the only things that trigger any vomiting in her and it is a very rare occurrence with her, as is diarrhoea for that matter). This morning Saoirse had severe abdominal pain. She did not eat or drink anything overnight. I got an emergency consult with the vets. Thus far, treatments received are: 10:30 BST: Vet injections - bupe, vitamin b12, Cerenia, Betamox 3-day antibiotic. 15:00 BST: Ondansetron 2mg Saoirse was still in a lot of pain and not wanting food so called the vets' OOH service. 16:02 - Vet administered Metacam injection to help with acute pain management. 17:21 - Pain response lessened. Saoirse ate a little puréed low carb food / water mix from my finger but started growling after a couple of teaspoonfuls. PMBG: 8.1 (dose withheld due to inappetence / 7-day average BG at this time 8.7). AMBG: 11.1 (insulin dose withheld again). AM blood ketone level: 0.1 mmol/L. (Alphatrak glucometer / human ketone meter) Saoirse is to get 0.2ml bupe every 6 hours. I am in bits over this. Saoirse has been doing so well over the last couple of months - better regulated BG, blood pressure back in the normal range, pigmentation normalising, healthy and steady appetite, overall contented and happy in herself in spite of the diabetes and other issues. In the days after the first bout of diarrhoea resolved she was very well - coat soft and shiny, terrific appetite, purry and affectionate. It is soul-crushing that she's now really unwell. It is agony to know she is hurting. I'm really scared about this flare. Please pray and send positive thoughts for my girl; she is in great need of them. Questions to follow in another post very shortly. Mogs .