I desperately need help. I will refer you to a couple of threads and then summarize where am at: Intro forum: http://www.felinediabetes.com/FDMB/threads/meet-warren-again.136271/#post-1424641 Lantus forum: http://www.felinediabetes.com/FDMB/threads/5-4-warren-amps-518.137335/ Warren was diagnosed with diabetes a bit over a year ago. He was on Vetsulin for a couple of months and went into remission for almost a year. When he started having problems again, I had a full lab workup done, urinalysis, blood, physical, etc and my vet said the only health issue Warren has is his diabetes. In Warren's 15 years, he has NEVER had issues with behavior.... problems using the litter box, etc. I put him back on Vetsulin but it did not last more than 8 or 9 hours. After perhaps a month of Vetsulin, I switched him to Lantus (a month ago). In that month I have not been able to regulate him. 1 unit pushes his blood sugar too low (40s) and the Lantus can last as long as 16 hours. 0.75 (approx, no way to measure exactly) doesn't seem to be enough. You can examine the spreadsheet, I have probably 150 data points over the month and a couple of curves. He has been peeing on the kitchen rug, so I placed a litter box about 5' away in the bathroom. When he is locked in the bathroom, he uses it 100% of the time. When I let him out, he uses the rug too often. My wife has sentenced him to living in the bathroom and wants me to have him put to sleep. She will not tolerate any more peeing outside the litter box. The ultimatum is coming and I feel like I'm just about out of things to try. I believe the peeing problem is related to his diabetes being unregulated. His levels looked reasonably stable the past 48 hours (200s-300s - not great numbers but first time I've seen him out of 400s and 500s for this long of a stretch), I was hoping we were finally starting to stabilize, then he peed on the floor and I checked and he had bounced (556. First time he'd been over 400 in 48 hours). My wife feels his peeing is behavioral since he has an option of a litter box 5' away from where he is going. Warren does not seem stressed in any way. He's happy, purring, playful, sitting in laps, he's his normal self. I need a plan I can communicate to my wife and be able to tell her 'if x,y,z doesn't work, I will have him put to sleep'. I don't know if he'd do better with Lenevir, that's one option, but from what I've read it seems when Lantus doesn't work, it's because it's not bringing down the glucose levels, which is not what I'm experiencing. I'm not in a position to throw a lot more $$ at shots in the dark, again my wife feels I have spent enough $$ already on an "old cat" (an awesome old cat) but I can probably get away with a few hundred. I just lost my Mom in March and really hate the idea of saying goodbye to another close friend when there may be a straightforward solution. Any help is greatly appreciated. Thanks everybody.