Working with MPM to get numbers down

I feel like we are back at where we started with all pink today. Is it ever possible to find a dose that works and stick to it or is it always an up and down thing? For awhile it seemed like we had him settling down but now here we go again. . .
 
Are you happier with last night’s numbers? I hope you got some good rest. You need to think about your goals for Opie. Everyone has different goals for their cat. Some people are determined to try for remission for their cat. That requires many sleep-deprived nights unfortunately. Other people are content just to try to regulate their cat in higher numbers (like the goal of SLGS which is to keep them between 90 and 150 as much as possible.). Of course, we’ve already talked about how you can modify things a little bit to suit your goals and needs.
 
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He is NOT on dry food. This was an emergency only situation and something I could get him to eat readily and happily.
Yeah, big difference between this and feeding a regular, daily portion of dry, no matter how much.
Is it ever possible to find a dose that works and stick to it or is it always an up and down thing?
This is a loaded question! If they follow the plan, you'd start low, increase until you find a good dose that has him spending time in the healing green numbers and as the pancreas heals and starts helping out the dose gets reduced until they reach remission - you know there's a but coming....but, it doesn't always work this way.

Here's a good read (That I absolutely love) that explains what's going on with our FD kitty's, see Post #9 & #13.
The Pooped Pancreas story
 
I’m going to copy and paste a response from one of our moderators to another new member who is struggling with a lot of questions. A few of the things she says in here may be helpful in answering some of your concerns. I was going to say some of these same things in response to your question of last night, but then this morning I was reading this and thought I would just copy and paste it. This member is using Lantus insulin, but nevertheless a lot of the information applies: Wendy said:

“You asked me several questions in a PM:

but would you mind taking a moment to look at Jessi's spreadsheet and give me your opinion on what to do next? We did back to back reductions that have caused quite a lot of change and I'm concerned that now she's slipping back into a hyperglycemic state, not just in numbers but in how she's acting.

I know it could be other factors as well, but I would just like to hear your take on it. Several people have responded suggesting I do TR but that doesn't help me understand the SLGS method and what to expect in the next 24-48 hours, what to do if she stays up in these numbers, and other aspects of the method.

Doesn't back to back reduction cause a sudden release of stored insulin into the bloodstream, couldn't that be why she had that long stretch of low numbers the other night? If this is a known effect of doing the reductions so close together, wouldn't we want to slow that down more? And if this happens, does that deplete the depot that is so important to the Lantus effect?

Can a bounce cause higher numbers even 2 days after the low ones? How do you know if it's a bounce or just not enough insulin?

Sorry for all the questions, I'm just trying to understand the thinking and science behind this method so I don't feel so in the dark. Whatever knowledge you can share would be great.

It's hard to see her so low and lethargic after seeing her spry and energetic the last few days. Maybe it has nothing to do with the reductions at all, but I feel like the more I know the more empowered I will be.

Click to expand...
First piece of advice is to learn to relax and take some time to do some things for Stefania. All of us start out as helicopter parents, trying to interpret everything our cat does. You might want to read this post: Dear Mom/Dad (letter from your kitty)

Feline diabetes is a marathon, not a sprint. We also say that Lantus teaches you patience, which definitely was not a word to describe me when I started here, so I can relate to the million questions.

Jessi is bouncing. Bounces can take up to 3 days/6 cycles to resolve. Bouncing and the phrase "my cat's numbers are all over the place" are the two mostcommon complaints we hear from new caregivers. You know what, this is not something we can control. It happens and it takes much more time in normalnumbers to reduce or stop bouncing. My cat took a year to stop bouncing to over 400. And note, we have a phrase that you have to Learn Your Cat and ECID, each cat is different, because it's true. Over time, you might learn to predict Jessi's patterns on Lantus. At which point she'll change those patterns, because CAT. :cat:But the basics of when she onsets, and her response to carbs should stay pretty much the same.

We cannot do anything about back to back reductions when following SLGS, and we sense your frustration with having to hold the dose a week now (unless she goes under 90 again), which is probably why people are suggesting trying TR. You test enough for it and are feeling low carb food. In spite of that, we say that the choice of dosing method is also a matter of your life style, goals for Jessi, and comfort level. Some people just aren't comfortable with the concepts of TR, and that's OK if you want to stick to SLGS. However, that means changes have to be done more slowly iffollowing SLGS. You will have to stay with 0.5 units for a week, so 11 more cycles.

Not just back to back reductions, but even single reductions will feel the effect of the higher depot for 4-6 cycles after the reduction. In that case, you may wish to help prevent her earning another reduction prematurely. Yesterday you saw a huge drop from +2.25 to +3.35. That might have been a good point to give something like medium carb, to try so slow her down and prevent her from going under 90. Rather that waiting until she went under 90 to boost her up. Learning how sensitive Jessi is to carbs will help immensely. I see you are noting when and what you feed (excellent), you might also want to note the amount.

Another suggestion for you, look through the posts on this forum and look for people who have recently diagnosed cats. Read their posts, look at theirspreadsheets. A lot of the same questions get asked, or you might find one you had not thought of yet. You may also see some similarities between newly diagnosed cats and their response to insulin.”
 
I have a lot to read through with your last posts and although it was nice to have the 115 numbers last night, I did fall asleep too soundly and missed the alarm to test again a couple of hours later to see where he went. I did not understand that by having the numbers in green his pancreas might actually heal. From what I gleaned from google, it seemed that healing or remission could only take place soon after the start of insulin and not almost 2 years into it so I only hoped for lower numbers rather than staying in the pink as I was. There's a lot of information to be had here but I wish it was explained from the onset what the goals could be and the different methods to achieve them and why, and what is possible and what is not etc.

I did not know how to decide on a method and how they differed with results.

what is TR? tightly regulated? and why is it not in the abbreviations page?
 
what is TR? tightly regulated? and why is it not in the abbreviations page?
TR is the 'Tight Regulation' Protocol specific to Lantus or Levemir.

Modified Prozinc Method or as some of us call it, MPM, is the Prozinc specific, more aggressive protocol to follow for tighter regulation using Prozinc.

I did fall asleep too soundly and missed the alarm to test again a couple of hours later to see where he went.
Don't beat yourself up - you were exhausted, you needed a good sleep, period. We know exactly what you're going through. (If you look closely, you'll see a few missed alarms on my spreadsheet too:oops:)
 
Ok so this is my understanding so far. . . with MPM, you want to keep them at a dose that lets them go into the green as long as possible and you use food to keep them from going down too low under 50. The green being the healing spot. This is tight regulation. If this gets too difficult or isn't possible then we have the option of SLGS which gets them some green but also low blues and doesn't get so dangerously low near 50. I guess the blue isn't healing like the green but is the next best?
 
Normal numbers for a cat are somewhere between 50 and 120 so anywhere in there would be healing numbers. Non diabetic cats really can be in the 40s too — just on their own — but that’s definitely not where we want our cats on insulin to be since the concern is that the insulin could push them into symptomatic hypoglycemia.

I have seen cats on this Board go into remission after being on insulin for a long time.

Trying for remission can be tough. Really tough. Not everyone will be able to go for that — and sometimes, I’ve seen times where the cat takes the lead and just starts earning reduction after reduction and just goes into remission. It’s different for every cat. But most of the time people have had to work really really hard for it. There’s not a right or wrong answer here. People’s lifestyle, personal health concerns, stress levels, schedules, number of other animals (sometimes with health problems too) all play into what is the best way for that particular caregiver to manage the diabetes.

I think you asked about this too: one strategy to keep a cat from earning a reduction is to keep them from dropping below 50 (MPM) or 90 (SLGS) by using food and varying levels of carbs to keep the BG up above whatever the reduction point is. That is also a lot of work at times. The reason a person would want to do this is to keep from reducing the dose and having the cat go into higher numbers that aren’t considered the healing numbers. This is a labor intensive technique. It does not put the cat in danger because the caregiver is in control when they are testing and feeding the cat. However, it is not for everyone.

Note that this is not the same thing that I was encouraging you to do before when I was having you give Opie snacks during the early portion of the cycle. The purpose of that feeding is to provide enough food/carbs so that he would not drop too quickly and trigger a bounce. His BG will still drop from the insulin, but at a slower pace.
 
thank you for clarifying that for me, it helps a lot :)

today he went up pretty quickly before his +6 time, almost ready for his PMPS now. . . thank you for being there for me
Just fire away with any questions that you have — even if you have asked them before. We will do our best to explain. It’s a journey and, as everyone always says, a marathon and not a sprint. You’ve been at this for a while now, too.
 
Normal numbers for a cat are somewhere between 50 and 120 so anywhere in there would be healing numbers...... Note that this is not the same thing that I was encouraging you to do before when I was having you give Opie snacks during the early portion of the cycle. The purpose of that feeding is to provide enough food/carbs so that he would not drop too quickly and trigger a bounce. His BG will still drop from the insulin, but at a slower pace.
Excellent post Suzanne!

I've always thought slowing down the fast drops is so important, more often than not, it's the fast drops that cause the worst bouncing. We want them spending as much time in lower numbers as possible but we don't want to slam them there, we want to soften the drop early with food when needed, get them there gently so the liver doesn't panic, go into high alert mode and dump everything it's got in the bloodstream!

(PS, I'm not around as much during the week, but I'll be watching when I can)
 
Excellent post Suzanne!

I've always thought slowing down the fast drops is so important, more often than not, it's the fast drops that cause the worst bouncing. We want them spending as much time in lower numbers as possible but we don't want to slam them there, we want to soften the drop early with food when needed, get them there gently so the liver doesn't panic, go into high alert mode and dump everything it's got in the bloodstream!

(PS, I'm not around as much during the week, but I'll be watching when I can)
We are very happy to have you here whenever you can be here. I know I am!
 
strange. . . I got an email with a message from you about increasing the dose and I look here and it isn't here at all. . . anyway, tomorrow AM is the 6th cycle so I don't think that is the increase yet is it? and PM might not be the best to increase do you think or does it matter? Opie is crabby and not eating as well, being finicky. . . .
 
strange. . . I got an email with a message from you about increasing the dose and I look here and it isn't here at all. . . anyway, tomorrow AM is the 6th cycle so I don't think that is the increase yet is it? and PM might not be the best to increase do you think or does it matter? Opie is crabby and not eating as well, being finicky. . . .
I never liked to do increases in the evening. I almost always waited until morning (well... even though I was up a lot at night anyway... it just felt safer to do increases in the morning, although sometimes I was so impatient I would increase in the morning.)

I'm still thinking about the increase. Get right back with you.
 
Let's see what he does for the rest of today and tonight. He's had a few lower blue nadirs, but more recently they were a little higher. I do think you will want to increase and, as I said, I don't like seeing so many yellows. But now that I've said all that... Opie may decide to teach us a thing or two and surprise us! So, I'm not sure yet, you may want to give it one more day, but let's wait until today and tonight are "in the books" (or "on the spreadsheet!")
 
Let's see what he does for the rest of today and tonight. He's had a few lower blue nadirs, but more recently they were a little higher. I do think you will want to increase and, as I said, I don't like seeing so many yellows. But now that I've said all that... Opie may decide to teach us a thing or two and surprise us! So, I'm not sure yet, you may want to give it one more day, but let's wait until today and tonight are "in the books" (or "on the spreadsheet!")

He just went down to 66. . . go figure. . . . yes, I am prepared to do whatever I need to for Opie AM or PM.
 
Can you tell me what/when he ate today? That is a big drop to his nadir. Obviously, he doesn’t need that reduction!

I see he’s bounced tonight. It’s not surprising after today’s greens.
 
Can you tell me what/when he ate today? That is a big drop to his nadir. Obviously, he doesn’t need that reduction!

I see he’s bounced tonight. It’s not surprising after today’s greens.

Ha! Ha! yes, the threat. . . . he didn't eat well this morning or all day in fact. As I mentioned, he is just 'off' today. I got him to eat a bit more after he went to the 66 but I think he went down that much because he didn't eat good earlier, only 1/2 can FF classic pate before AMPS. He ate bits on and off but not his usual. We force fed him after his PMPS to make sure he won't drop quickly tonight, 1 whole can of FF.
 
Opie hasn't been himself and is not eating as good since we lowered the dose to 2. There is a definite difference in him. We will wait for the 6 or 7 cycles to make sure and I will wait to see what you think before increasing. Let's talk about it tomorrow ok? and thanks for letting me know that I did good :)
 
Last night he went down real slow, I guess because I fed him a whole can with PMPS. This morning he only ate 1/4 can FF pate before AMPS so we force-fed the other 3/4 can after the shot. He was at 230 which was good but low for the start of the day, at least for what he has been.
 
At +3 he went down to 83 and he ate 1/4 can FF classic pate. At this point I don't think we will need to increase the dose. I think that what I said about him being 'off' is due to the added tests all day and now night and he is getting cranky about it and stressed. He used to come right away when I call him and now I have to chase him all around the house. I guess the exercise is a good thing, right? LOL
 
Yikes! Looks like we are going to Decrease instead. . . is at 34 at the +6 time. Gave Karo syrup and a small bite of food, just FF classic LC.
 
oh my goodness. I was going to say no increase but yes, definitely decrease. Where is he now BG wise. I'm worried. Keep checking him to make sure that he won't drop back down. Karo wears off quickly.
 
49 is still too low, I would give more Karo still unless you have some FF GRAVY LOVERS HC food on hand. You should give some HC food anyway. Keep testing every 20-30 minutes and keep an eye on him. Don't let him get away from you where you cannot reach him. Whenever HC food and/or karo is given then you need to keep testing for two hours after the HC or karo is given to make sure he stays up on his own.
 
So, having said all that about testing Opie every 20--30 minutes I want to add that, when you first saw this morning that he had dropped to 83 from that AMPS of 230 -- which is a very large drop -- that should be a sign for you to start feeding him MC (I would have gone for something about 15 percent carbs) right away and to check him again in about 30 minutes to make sure he wasn't dropping further (which he was). You could have headed off the 30s, which are dangerous. I'm not even talking about avoiding a reduction here, because I really was thinking that he was heading for a reduction based on previous days' numbers, but I'm just talking about feeding him to keep him from dropping below 50! Okay?

A lot of people will get their various cans of food with different carb levels in them and take a Sharpie pen and write on the top of the can what percentage of carbs are in that particular food. This way in an emergency, you can grab what you need right away. If you don't have any of the mid-carb type food on hand, then what you can do is mix a little Karo into some regular LC food. But Karo wears off quickly.
 
So his new dose is 1.75 units for tonight. If he has a really low preshot tonight you probably will want to do a reduced dose.
 
So his new dose is 1.75 units for tonight. If he has a really low preshot tonight you probably will want to do a reduced dose.

Thanks for your help. He is at 156 right now and there is another 2 1/2 hours until PMPS. He will probably be around 200 or more. So far , no bounce! He seems to be quite sensitive to carbs and I think an MC food would have spiked him too high. I was happy that he stayed in healing green as long as he did today. I must say though, he doesn't show any signs of being low when he is low so I have to be very vigilant.
 
Well here's the bounce. . . we are at 375 PMPS time. The dose is now 1.75. I was sad to see how high he went but it is to be expected. He went as fast down this morning as he went up for PM. That certainly is a big curve. . .
 
I may have already mentioned this food tip that works for me and Newman.

Sometimes he just sits and looks at his Fancy Feast. But if I sprinkle crumbled Pure Bites Freeze Dried Chicken, he is pushing my hand out of the way with his head to get to that food. The pure bites have to be crumbled to break up the chunks or he would just pick them off.
 
I may have already mentioned this food tip that works for me and Newman.

Sometimes he just sits and looks at his Fancy Feast. But if I sprinkle crumbled Pure Bites Freeze Dried Chicken, he is pushing my hand out of the way with his head to get to that food. The pure bites have to be crumbled to break up the chunks or he would just pick them off.

thanks for that suggestion
 
I may have already mentioned this food tip that works for me and Newman.

Sometimes he just sits and looks at his Fancy Feast. But if I sprinkle crumbled Pure Bites Freeze Dried Chicken, he is pushing my hand out of the way with his head to get to that food. The pure bites have to be crumbled to break up the chunks or he would just pick them off.
I do that, too, Linda. Around here we call ot Magic Chicken Dust!
 
I am worried because he ate very little and he is now at 140 with less than 2 hrs before PMPS. He doesn't look like he is going to go higher.
 
Can you make him eat? Honestly if he’s not higher than 140 at shot time I would not shoot after what happened yesterday with the lime.
 
waited a half hour then retested and got 225 so I shot just a bit less at 1.5 and will have to check him often. He is getting very stressed with all the testing. Being upset, he is not eating, well he has an appetite but he refuses the food I give him and is stubbornly holding out for something he wants and I don't yet know what that something is. Not eating is making his numbers low.
 
I see he’s down to 144. Can you give a snack.

gave a bit of a snack but will wait until he goes into the healing green to do a lot more, will monitor closely. Could use your advice on dose in the morning since I gave 1.5 instead of the 1.75 and he is still dropping fast.
 
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