I'm sorry to start a negative thread, but we are not seeing anything positive at this time. Our internist vet who we've been working with has her up to 13U 2x Prozinc after seeing some slight decrease in #'s. But, Cleo's activity level, intense hunger, bad behavior (nipping, begging, leave me alone etc) has not been good the past several days. I can't believe a cat can eat so much and do so little. Today we had the talk w/ our family vet who initially dx'd her w/ diabetes last August, and she said we are getting to the point of letting go might be the best thing. She praised us for our diligence through all of this, and said we've done more than most cat owners. At this point, we can't travel and board poor Cleo because of her hunger, litterbox maintenance issues and insulin needs, plus she would get so stressed out having to stay at a vets kennel for a week I think the cat would just be in misery if we left her. If you look at her SS you'll see hardly any change in relation to the increase in insulin dose. It seems the harder we push w/ insulin, the harder the disease pushes back. The cabergoline and zobaline seems to have no effect. Since I work from home now, I've been able to monitor Cleo much more than if she was by herself normally during the work week so she's getting lots of attention. We can tell she doesn't feel good and has no energy. She holds urine then pee's a big puddle in the box. Her thirst is a little above normal. She's still using the box ok, but tracks urine and wipes her bottom on the towels we leave around the box at night. I'm getting prepared and it's very hard.