I did a dose increase because Marley's number were kind of flatlined and not moving. I went from 2.75 to 3.25. After 3 days, there was a little change, but not much. Since nadir was still 200+, I bumped it up to 3.5. Well, this morning his number was so low that I wasn't comfortable giving a full dose and gave just 2.75. I don't want to do reduced doses and prefer to lower the dose if that happens, but I just increased from a dose that wasn't helping him. I also know that dose increases can be weird until the body "levels out." If a lower PMPS happens again, should I just do the full dose and closely monitor him rather than a reduced dose? It's just so strange how drastic his numbers get. It's like a pendulum that keeps swinging to extremes. He was also obviously feeling incredible this morning based on his playing, running, jumping, and happiness. So I'm happy to see this with the lower numbers, but it's incredibly frustrating not being able to find a dose that works for him.