http://www.felinediabetes.com/FDMB/threads/5-14-billie-pmps-301-6-157.195594/#post-2190407 Hello all! Billie's bloodwork came back, and wouldn't you know it, the methylpred really was helping her liver/triaditis. Her GGT was back in normal range...her total bilirubin went from 5.8 to 0.7...ALT went from 800 to 398...ALP and AST also went down significantly. All in two weeks. Unfortunately, we know the methylpred put her into congestive heart failure, so it's not an option. However, she responded to it liverwise, so her IM's thought is that maybe she will respond to another immunosuppresive/anti-inflammatory drug. Right now, the focus is on getting her heart back to normal with 6.25 mg of furosemide once a day, recheck in a week. But her IM said that if she stays stable over the next couple days, we could try Atopica or Leukeran. I'm going to do more research on both. If anyone has experience or thoughts about either, please chime in! I know both can have some challenging side effects like inappetance/nausea. I know longterm use of Atopica can increase the likelihood of developing cancer, while Leukeran is a chemo drug...and I know Leukeran has the potential side effect of bone marrow suppression. We really don't know if Billie's liver disease is triaditis (inflammatory) or cancer because we haven't done biopsies, but her IM leans toward triaditis based on the slow progression and the response to pred. But she did say that some cancers respond to pred as well. Before the bloodwork came back, I was really thinking we had reached the end and wasn't going to try more treatments. But, if her liver values turned around like that, it makes me think she can get better and might want to stay around a while She is currently sleeping curled up in the tire...which is still on the floor in the apartment, because if Billie wants a tire in the living room, Billie gets a tire in the living room I bought the girls two new super soft cat beds a few weeks ago, and Billie wanted nothing to do with them, but a tire is somehow appealing to her... @Wendy&Neko , I think Neko is the only one who would understand! Billie is still eating well even with the steroid out of her system. Her respirations are a little elevated, but her effort is normal. She was less lethargic and more active today. She had been staying in the bedroom a lot over the past few days, but today she also hung out in the living room. Vines and hugs to all!