Hello all from Toronto, Canada. Sorry for the long post and thank you in advance for any suggestions you might have. Bruno is around 10 years old and have been diagnosed in August. When he adopted us in the shelter 2 years ago, we were told that he has pancreatitis and was recommended to use Natural Balance Limited Ingredient Diet Salmon and pea variety as his main diet choice. He has been on the dry food version for 2 years and we have given him a can or two of the wet version once a week as a treat. I began to notice that he was drinking twice the amount of water as usual in July and since we had an abnormally hot summer, I suspected something might be up but was hoping it would go away when the weather cools. It didn't. We took him to our vet who did a blood/urine panel and his blood glucose was 360(since we are from Canada, I just multiply our number by 18). He was 16 lbs when we first got him and he was up to 19 lbs in July. He was down to 17 lbs at the time of diagnosis in August and is now 15 lbs. No ketones in the urine. I then came across Dr. Pierson's website about the high carb content of the commercial dry food. I got ourselves an Onetouch meter(which is really similar to the one that our vet uses) and started home testing him. Before we tried insulin, we put him on the wet version of Natural Balance salmon and peas(12% carb on Dr. Pierson's chart) for a week. We did a fasting blood sugar test in the morning for a week. The average reading has been around 350 for the week so no improvement. Our vet recommended that we used Lantus(Glargine) and we started in early August with 1 unit twice a day (8AM and 8PM). Initially we gave him 1.5 cans of the wet food per day and had to move it up to 2 cans to stop his weight loss. Our vet asks us to do a blood glucose reading 6 hours after the AM shot at the end of the week and reports to her. Since we are home all day we did a +6 hours reading every day. I also did a curve as per the instruction in the "Start low, go slow" page but Bruno was hopping mad at being poked 7-8 times a day so we have only done it once. I kept a spreadsheet of the number of unit of Lantus, his glucose number, what and amount of food we fed him, the amount of water he drinks in a day, number of times he pees(number of clumps in the litter box) and whether he has a bowl movement. We have tried changing his canned food from Natural Balance's Salmon and Pea(12% of carb) to the chicken variety(10% of carb) and eventually moving over to Dr. Pierson's(0 carb) recipe. We even tried giving him Purina Classic chunky chicken(4% of carb) to see if it makes a difference. Here's summary of the results. Week 0 - no insulin, 1.5 cans of NB's salmon. Average reading fasting is around 350. He was 17 lbs. Week 1 - 1 unit at 8AM/8PM, 1.5 cans of NB's salmon. Average reading at +6 hr is around 340. Week 2 - 1.5 unit, 1.5 cans of NB's salmon. Average reading +6 hr is around 340. Down to 16 lbs. We bumped his food to 2 cans since he is still losing weight. Week 3 - 2.0 unit, 2 cans of NB's salmon. Average reading +6 hr is around 330. Since there has been no improvement, our vet suggested we increment by 1 unit instead of 0.5 unit. Week 4 - 3.0 unit, 2 cans of NB's salmon. Average reading +6 hr is around 330. During week 4, Bruno came down with a bout of runny stools and 2-3 bowl movements a day. We went to the vet and he had a stool test for parasites, urine analysis and bacteria culture test. Everything came back normal. He was on a week of antibiotics (Tylosin 50mg) and his diarrhea is gone by the middle of week 5. I have been thinking of switching from NB for a while since the consistency of the "food" in the can has been erratic and is really "hard" out of the fridge. I have had to put drops of water in before he can eat it. So for week 5, we switched to the chicken and pea variety of NB Limit ingredient diet. Week 5 - 4.0 unit, 2 cans of NB's chicken. Average reading +6 hr is around 300. Finally a little bit of improvement. The first day of week 5, his reading was 208. I don't know whether it's due to the increase in insulin or switching can food so in the fifth day of week 5, I gave him 2 cans of pacific wild salmon that he loves and nothing else. The reading of 192 on the first day and then 240 for the next 2 days. This is what prompted me to try giving him purely meats using Dr. Pierson's recipe. Since we are making a drastic change, we kept the insulin at 4 unit for week 6. Week 6 - 4.0 unit, 6-9 oz of Dr. Pierson's diet. Average reading +6 hr is around 300. The reading on the first day was 162. Nothing like normal but a big improvement. It then starts to creep back up in the next few days. We started off with 6 oz (4-6 oz according to Dr. Pierson's suggestions) but he was really begging for food and is down to 15 lbs so we ended up with 9 oz. This brings up to week 7, this week. We are up to 5 units. First day's +6 hours reading was 220. PMPS was 270. A step in the right direction and this is the first time that any of our PMPS or AMPS reading being less than 320. However, for the next 3 days, the reading was back up to 300s. The AMPS this morning was 400, the highest we have ever since. This has been an exhausting 2 months. I have re-read the material I have and tried to come up with new solutions. I have a feeling that 5 units of Lantus is quite high already and our vet says she would be happy with a consistent +6 hours reading of 200. We had gone to the vet and did the shot in front of her. I have also done this so many times that I know when I screwed up and did a fur shot. Our vet also did a blood sugar test with Bruno with her meter so we know our meters are ok. I also did a reading on myself once a week to make sure. 1. Am I feeding him too much at 9 oz a day? I came up with 9 oz to stop his weight loss. 15 lbs might sounds high but it's heart breaking to see him shrinking. I am also only feeding him pure meat(chicken thighs, chicken livers, eggs, ionized salt and a vitamin soup). No carb at all. He also has trouble jumping with his weak hind legs. He was able to jump up the 5 foot high cat tree as recently as May/June. Our vet mentioned that the weak hing legs problem could resolve itself once we get him regulated. I will mention methyl-B12 next week when we go see her. 2. The FAQ suggests fixed schedule feeding at around the 2 shot times. Currently our free style feeding schedule is like this. Bruno would wake me up at around 5:30AM. He gets a small feeding and I go back to sleep. He gets a small feeding at 8AM before his morning shot. He gets a big feeding at 10AM where I usually have to go out for a while. He has a small feeding at 2PM before his blood glucose test. He has a small feeding at 6 pm and one at 8pm before his second shot. He then gets a big feeding at 10PM before I go to bed. I will try the fixed schedule feeding for the next couple of days to see if it makes a difference. 3. Our Lantus bottle is 1.5 months old. Should we get a new one? They are quite expensive at $80 a bottle and we have been very careful as to not shake it and keep it in the fridge at all times. What I found interesting and do not comprehend is that the first day of us changing a variable(ie giving him chicken variety instead of salmon, giving him just canned salmon only, giving him Dr. Pierson's diet, going from 4 unit to 5 unit), we see a sizable improvement and then the glucose level will always creep back up over the next few days. I have read that it takes some time for the body to adjust to the new insulin level but it's frustrating to say the least. In hindsight, maybe I was changing things around too much. For now, I will keep giving him Dr. Pierson's diet since I know exactly what's in it. He has no problem with constipation on the new diet and his stools look much better than before. 4. Maybe he needs something else other than Lantus? We have an appointment with our vet next week after our first week of 5 units. Again, sorry for the extra long post and thank you for listening. The first day I met this guy, he jumped up and sat on my lap. I will do anything I can to make his last few years on this sweet Earth as enjoyable as possible.