Yum had a UTI right before I left her at the vet for a Thanksgiving trip. Her numbers varied wildly at the vet. They did a curve this past Monday and she went from 714 to 189 (AT2) on 2 units twice a day (from maybe 8 am to 4 pm). When I picked her up Tuesday I didn't know if she was going low at night and bouncing, or if the high numbers were due to stress from boarding, or maybe continued infection. I skipped a shot and took her back to pre UTI doses of 1 unit twice a day. Big mistake. I have been ramping up the dose every 3 cycles since then---I looked at it as a failed reduction from the 2 units she was getting at the vet. So far today she hasn't gone below 546 on 2 units twice a day (3rd cycle). I will increase it to 2.5 units this evening. I would guess she has glucose toxicity. I need to get her numbers down ASAP. I hope to see at least 400's tomorrow. Am I waiting too long to try a short acting insulin at the ER? She didn't have ketones yesterday. She has never had ketones. Of course these numbers are worse than our pretty rough initial regulation last March. She gets her last dose of the antibiotic Orbax tonight. Do cats usually pop back down after infection? Or does the infection damage the insulin production and result in the need for higher doses? I know glucose toxicity causes more damage and possibly organ damage. She developed kidney disease post diabetes diagnosis this year.