Leo (Leoberry) - the high doser

Discussion in 'Acromegaly / IAA / Cushings Cats' started by JeffJ, Aug 25, 2016.

  1. Sharon14

    Sharon14 Well-Known Member

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    Aug 16, 2015
    Poor little boy. I hope the meds work and he starts feeling better soon. Give him some scritches from me!
     
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  2. apple

    apple Member

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    Apr 15, 2017
    Sending lots of vines for Leo and you.
     
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  3. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    Thanks
    1) Tube site - cleaning with chlorhexidine and then applying a salve. Reviewing daily. I'll look into silver Sulfadiazine.
    2) eating - Leo ate about 1/3 normal today. And was a bit more active.
    3) Chlor - we are getting liquid. I will be applying it thru the feeding tube.
    We receive it on Monday. I was surprised it was so inexpensive - $25 for 2 month supply. Heck, flea medicine costs more than that.

    LD was helping Leo feel better tonight. Our sweet boys.
     

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  4. Wendy&Neko

    Wendy&Neko Well-Known Member

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    Feb 28, 2012
    Is that "Chlor" liquid chlorambucil? The SCL group is very much against using the liquid form. It is too easy to contact it yourself. Chlorambucil is a carcinogen so you need to be very careful when handling it. And when I inquired about it, the shelf life of the liquid form was something like a week. In the US you can get the dose compounded into a capsule. I just used the Leukeran pills (which have a coating) and used gloves to handle it.

    Leo looks pretty relaxed in that photo. Good to hear he's eating a bit. :)
     
  5. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    We will be using gloves, and maybe a mask just in case. It is compounded into a liquid - chlorambucil.

    It sounds kinda weird that a chemo drug that kills cancer is itself a carcinogen. I haven't read much about it. Here is it 1:20am, and I finished working around 12:30am. Trying to get a data center (set of servers) ready for an audit.
     
  6. Sharon14

    Sharon14 Well-Known Member

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    Aug 16, 2015
    Nice pic! Sounds like Leo is feeling a bit better. Good luck with the chlor.
     
  7. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    I posted a Q and A about SRT on the Acro forum here.

    Leo got his tummy stitches out on Monday - from the biopsy surgery. His shaved belly is NAKED! and so soft. The wound is hardly there. I know everyone wants to rub it, so I rubbed his tummy for all of you :D

    Leo has been getting prednisolone as a precursor treatment for his Small Cell Lymphoma (SCL), a few days ago. The good side effect was an immediate appetite increase. He has been eating a lot. He lost a lot of weight in just a month, so we are happy with the increased eating.

    Leo started chemo today. We are doing the "Every Other Day" EOD protocol with Chlorambucil liquid to start. No side effects yet since he just started. I hope we can knock this cruddy cancer into submission. My sweet boy, my little trooper.

    Spreadsheet - new leftmost tab for 2nd half 2017.
    Drugs today: Insulin, prednisolone, chlorambucil, cerenia (for nausea)
     

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  8. Wendy&Neko

    Wendy&Neko Well-Known Member

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    Good to hear the pred had an almost immediate effect on his appetite! Good luck with the chlorambucil - I found the day after was when the nausea hit the worst, though it did last a few days.
     
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  9. Yong

    Yong Well-Known Member

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    Jan 11, 2017
    Been peeking in on the thread. It's amazing what you and Theresa are doing for your boys :). One of our Prozinc members had the same diagnosis but her kitty wasn't an Acro cat. I hope Leoberry is feeling a little better with the meds :bighug:
     
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  10. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    Thanks Yong. Someday, Leo will be gone. I hope this historical thread helps someone.

    Leo has stabilized. He is pretty tolerant of the chemo. The prednisolone is helping a lot - creating a great appetite. His weight is stable. If the chemo puts the SCL into remission, Leo could be loving us for years to come! I am hopeful for at least one more year.

    A new second tab on Leo's spreadsheet - shows meds and feeding method. We have a vet visit in the morning. I hope his feeding tube comes out. It smells, and he keeps trying to pull it out. I had to push it back in multiple times and affix it. I don't like the design, but won't rant further about it.

    I estimate we spend 90-120 minutes a day feeding, cleaning, medicating, etc, including the other 2 healthy cats. Aside from the high vet bill, the medicine costs are pretty small. Overall, the cost to keep a sick cat healthy is mostly a lot of personnel time. So I can understand why some people can't do it.

    June vet bills were $3,000. That's $2,000 for Leo's exploratory surgery, biopsies, tests, and the esophagus surgical implant of the e-tube. Plus the meds from the vet. And ~$800 for Little Dude's surgery and recovery from his outside 3am fight (he lost). Now LD is a 99% inside cat except for doing his duty. We have almost converted a wild cat to a safe inside kitteh. Lots of happiness there. Plus LD loves Leo. :)
     

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  11. JeffJ

    JeffJ Well-Known Member

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    Feeding tube out today - YAY. The insertion site looks bad, but with luck it will heal nicely. Weight is stable at 16.5 - last column on main sheet. Leo is real happy to have the e-tube collar off. :)

    Rewarded with a no-eating period after return from vet, then a minor Hypo. Recovery was fast, and eating resumed. Chart updated.

    Then dogs and Theresa were making noise and moving around during PM shot - and I probably did a fur shot. First one in 6 months. No more of that. We will now resume former protocol - they all need to be out of the room. So Leo will probably be 450 in the morning.

    Leo finished the day by eating a 1/2 can of Fancy Feast, 4 hours after chemo. We can't ask more than that!:cat:
     

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  12. Kris & Teasel

    Kris & Teasel Well-Known Member

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    Aug 17, 2016
    You do such a great job with your kittehs, Jeff! :smuggrin:
     
  13. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    Thanks Kris. It is a rewarding experience. Little Dude is totally healed, and acts like a kitten. It's great. He is a gravy loving addict.

    Leo is doing good. 7 chemo doses given since 7/5/2017. He doesn't have much nausea at all. The prednisolone is helping a lot with hunger, and maybe nausea. He is active, and plays a bit with LD. I'm keeping Leo's BG a bit high to avoid hypo territory. There is a threshold with Leo's insulin and if I cross it, his BG drops like a stone.

    I rarely talk about Chinus. She is Daddy's girl and stays by my side all the time.
     
  14. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    There is another SRT option through Pet Cure. They are a private company with multiple locations in the U.S. Unfortunately none are in Texas.

    https://petcureoncology.com/locations/

    This Thread <<<--- has a discussion about apple's experience at Pet Cure, and it was a good experience. I sure wish that thread had been posted to the Acro subforum.
    .
     
  15. Bronx's dad

    Bronx's dad Well-Known Member

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    Nov 30, 2016
    How is Leo doing?
     
  16. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    Thanks for asking. Leo is now
    - week 5 of chemo + prednisolone
    - 11th month post-SRT
    - 24 months insulin treatment

    He is doing great.
    - good appetite, probably from prednisolone, eats a lot, loves cooked/diced chicken and Fancy Feast, table scraps
    - good normal weight (16.5 - 17.0) with a little fat
    - alert, responsive, hydrated, nimble, playful
    - plays and wrestles with Little Dude daily...a sick cat wouldn't
    - CBC (blood eval) taken on Friday 8/4/2017...need to check results
    - BG is a bit high, hard to regulate, now at 4.0-5.5/dose, partly due to prednisolone
    - no noticeable neuropathy
    - thickened claws, that never became normal

    He has a small trouble eating. I feed him on stacked platters (4 inches high). I think soft tissue growth in his throat makes it hard to swallow. If I was a visitor to the house, he would appear as a normal healthy kitteh. We are approaching his 1 year SRT anniversary. Without SRT, he probably would be gone by now. Compared to last year, his improvement is dramatic. There were 2 or 3 times in the past 2 years we considered the "big decision". Leo is proof that dedicated and proper treatment can resolve deep issues for some kittehs, providing some life extension.:)

    Overall, it seems Leo is responding to the prednisolone. The blood work will verify if there is some chemo response. I believe the general goal is Small Cell Lymphoma (SCL) remission. He may be permanently on these drugs. The chemo is EOD (every other day), chicken flavored Leukeran in liquid suspension.

    Leo and Little Dude are the best brothers; it's great. They hang out quite a bit. I think a healthy social life with people and other cats is a contributor to cat (and human) health. About once a day they get supervised "out back" into a 40' x 100' fenced backyard for stimulation. Attached pic - 'Hi everyone, we are "outside" ' (10 feet from the back door). Our sweet boys.
     

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  17. Myagi and Heidi

    Myagi and Heidi Member

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    That album is so beautiful @JeffJ ! :bighug:
     
  18. Kris & Teasel

    Kris & Teasel Well-Known Member

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    Aug 17, 2016
    I agree! :smuggrin:
     
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  19. JeffJ

    JeffJ Well-Known Member

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    Jul 7, 2016
    Thank you. It's easy to get complacent about the online photo albums. Just updated LD's pics with last 2016 pics. (LD's 2016-2017 flickr page)

    Leo's health summary - January 2018
    - on chemo since July 2017 (6 months) and doing well, dose is now every third day as approved by oncologist
    - daily prednisolone tabs, no issues
    - BG averages: AMPS = 300, Nadir = 130, PMPS = 220
    - Levemir averages: AM = 4.5U, PM = 3.0U
    - 18.2-18.5 pounds (good), and good appetite
    - no noticeable neuropathy
    - December 2017 CBC values mostly normal

    Leo still appears externally to be a healthy kitteh. He is fairly active, and hangs out with Little Dude inside and on the back porch. Leo still loves people, and loves to sit in your lap when it's TV time. Leo has a big appetite, but still has swallowing issues. If we continue with this streak of luck, Leo will achieve his 12th birthday in April 2018. We are looking forward to it.

    (late edit - added pic)
     
    Last edited: Jan 7, 2018
  20. Myagi and Heidi

    Myagi and Heidi Member

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    Oct 30, 2017
    @JeffJ you're an amazing kitty dad! :bighug:
     
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